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Product : Antibody >>
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| Antibodies from IMGENEX: Cytokine & Chemokine |
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The immune system recognizes the presence of
pathogens by several proteins that bind to molecules secreted by the pathogen or
carried on their surface. The cells responsible for these immune responses
include the B-Cells, T-Cells, macrophages, neutrophils, basophils, eosinophils,
endothelial cells, or mast cells (Ref.1). These cells have distinct roles in the
immune system, and communicate with other immune cells by cytokines, which
control proliferation, differentiation and function of cells of the immune
system. Furthermore, they are involved in processes of inflammation and in the
neuronal, haematopoietic and embryonal development of an organism.
Unlike hormones, cytokines are not stored in glands as preformed
molecules, but are rapidly synthesized and secreted by different cells mostly
after stimulation. Cytokines are pleiotropic in their biological activities and
play pivotal roles in a variety of responses, including the immune response,
hematopoiesis, neurogenesis, embryogenesis, and oncogenesis. They frequently
affect the action of other cytokines in an additive, synergistic or antagonistic
manner.
Cytokines have been classified on the basis of their biological
responses into pro- or anti-inflammatory cytokines, depending on their effects
on immunocytes (Ref.2). Cytokines act in networks or cascades. Major cytokines
include the ILs (Interleukins), Growth Hormone, IFN (Interferons) and TNFs
(Tumor Necrosis Factors-Alpha and Beta). Many of the cytokines act locally like
autocrine hormones and their targets are cells of the same or similar type as
the cytokine-producing cell. A characteristic that significantly differentiates
some of the cytokines from hormones is the coupling of their activity to
cell-cell interactions. The function of some cytokines such IL-1, IL-2, IL-4,
IL-5, IL-6 and IL-10 is closely associated with the interactions between B-Cells
and T-Cells (Ref.3). IL-1 activates Antigen presenting cell and CD4+
lymphocytes; affect the differentiation of the B-Cells and T-Cells and other
immunocompetent cells and takes part in the regulation of productions of other
cytokines and GMCSF (Granulocyte-Macrophage Colony-Stimulating Factor) (Ref.6).
IL-2 stimulates the proliferation and activation of B-Cells and T-Cells. IL-4
plays a role in the differentiation of TH2 (T Helper Type-2), in allergic
responses, and in the switching of antibody types. IL-5 stimulates the
production and maturation of eosinophils during inflammation. IL-8 acts as a
chemotactic factor that attracts neutrophils, basophils and T-Cells to sites of
inflammation. IL-12 is a critical linker between the innate immunity and
adaptive immunity, capable of TH1 (T Helper Type-1) differentiation and
IFN-Gamma release by T-Cells and NK cells (Ref.4). IL-10 acts to repress
secretion of pro-inflammatory cytokines. IL-3 is a poly potent activator of the
hemopoietic cells. It stimulates NK-Cells and acts as a synergist with IL-4
during the induction of CD4+ lymphocyte activation process. IL-7 is known as the
growth factor of the immature B-Cells and T-Cells. It induces apoptosis of tumor
cells and causes differentiation of cells from a subgroup of acute myeloblastic
leukemia. IL-9 stimulates the excretion of IL-2, IL-4, IL-6, IL-11, and takes
part in a stimulation of cytotoxicity of T-killers and NK-Cells, inducing
apoptosis. IL-11 is a pro-inflammative factor, which regulates the functions of
B-Cells and T-Cells. It also takes part in the induction of various killer
cells' activities and acts as an autocrine factor for the proliferation of
megacaryocytes. IL-13 is very sensitive to the monocytes and B-Cells. IL-13 does
not act on T-Cells but inhibits the proliferation of leukemic pro-B-Cells. IL-14
is a BCGF (B-Cell Growth Factor) and the hyper production of this interleukin
enables the progression of NHL-B (B-cell type non Hodgkin's lymphoma). IL-15, in
the biological properties, is very much analogous to IL-2 and increases the
antitumor activities of T-killers and NK-Cells, and the production of cytokines
CD4+ lymphocytes. IL-17 is principally produced by CD4+ T-Cells, which induces
granulopoiesis via GMCSF. It takes part in the regulation of many cytokines and
can reinforce the antibody dependant tumor cell destructions. IL-18 acts as a
synergist with IL-12 in some of their effects, especially in the induction of
IFN-Gamma production and inhibition of angiogenesis. IL-19 is produced mainly by
monocytes and in its biological function is similar to IL-10. It is stimulated
by GMCSF and regulates the functions of macrophages, and also suppresses the
activities of TH1 and TH2. IL-21 executes an important role in the regulation of
haematopoiesis and immune response. It promotes a high production of T-Cells,
fast growth and maturation of NK-Cells and B-Cells population. IL-22 is produced
by activated T-Cells in an acute stage of inflammation. In its bioactivities, it
is similar to IL-10, but does not prohibit the production of pro-inflammatory
cytokines through monocytes (Ref.1). The complex interplay of these different
cytokine functions with immune cells is essential for correct immune function.
In addition to the above cytokines, the release of other inflammatory
cytokines, particularly TNFs (TNF-Alpha and TNF-Beta) from mast cells and the
associated recruitment of neutrophils are an important component of the
protective action of mast cells against infestation. The secretion of TNF-Alpha
and TNF-Beta by TH1 cells activates macrophages, inhibits apoptosis of
neutrophils and eosinophils, and induces vascular endothelial cells at the sites
of infection to change the adhesion molecules they express so phagocytes
circulating in the blood can bind to them (Ref.6). IFN-Alpha, IFN-Beta and
IFN-Gamma are produced in the area of infection during the early phase of immune
response. IFN-Alpha and IFN-Beta induce proliferation of NK-Cells and stimulate
innate and adaptive immune responses that are specifically targeted to virus
infections. Upon activation NK cells release IFN-Gamma, which activates
macrophages to secrete cytokines that help to activate macrophages to secrete
cytokines that help to activate T-Cells and promote the initiation of T-Cell
responses.
Cytokines play an important role in the communication between
cells of multicellular organisms. As intercellular mediators, they regulate
survival, growth, differentiation and effector functions of cells. Besides their
pleiotropic effects, cytokine actions are often redundant and they exert their
actions, which can be auto-, para- or endocrine, via specific cell-surface
receptors on their target cells (Ref.2). They are key players in the regulation
of the immune response, particularly during infections, inflammatory joint,
kidney, vessel and bowel diseases, or neurological and endocrinological
autoimmune diseases (Ref.5). |
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| Reference |
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Jason J, Archibald LK, Nwanyanwu OC, Byrd MG,
Kazembe PN, Dobbie H, Jarvis WR.
Comparison of serum and cell-specific
cytokines in humans.
Clin Diagn Lab Immunol. 2001 Nov;8(6): 1097-103.
PMID: 11687446 [PubMed - indexed for MEDLINE]
Heinrich PC, Behrmann
I, Muller-Newen G, Schaper F, Graeve L.
Interleukin-6-type cytokine
signalling through the gp130/Jak/STAT pathway.
Biochem J. 1998 Sep 1; 334 (Pt
2): 297-314. Review.
PMID: 9716487 [PubMed - indexed for
MEDLINE
Townsend MJ, McKenzie AN.
Unravelling the net ? cytokines and
diseases
J Cell Sci. 2000 Oct; 113 (Pt 20): 3549-50.
PMID: 11017869
[PubMed]
Xing Z.
Current understanding of macrophage type 1 cytokine
responses during intracellular infections.
Histol Histopathol. 2000 Jan;
15(1): 199-205. Review.
PMID: 10668210 [PubMed - indexed for
MEDLINE]
Evans CH.
Cytokines: molecular keys to homeostasis,
development, and pathophysiology.
J Cell Biochem. 1993 Dec; 53(4): 277-9.
Review.
PMID: 8300743 [PubMed - indexed for MEDLINE]
Vitkovic L,
Bockaert J, Jacque C.
"Inflammatory" cytokines: neuromodulators in normal
brain?
J Neurochem. 2000 Feb; 74(2): 457-71. Review.
PMID: 10646496
[PubMed - indexed for MEDLINE] |
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| Primary
Search |
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Immune System, Immune Responses, Immune Cells,
Immunocytes, Cytokines, IL, Interleukins, IL-1, IL-2, IL-3, IL-4, IL-5, IL-6,
IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IL-17, IL-18, IL-19,
IL-21, IL-22, Erythropoietin, Growth Hormone, IFN, IFN-Gamma, Interferons, TNF,
Tumor Necrosis Factor, CD4+ Lymphocytes, Th2, T Helper Type 2, Th1, T Helper
Type 1, Pathogen, B-Cells, T-Cells, Lymphocytes, Granular Lymphocytes, NK-Cells,
Natural Killer Cells, Proliferation, Differentiation, Inflammation,
Haematopoiesis, Haematopoietic, Embryonal Development, Viral Infection,
Immunocompetent, Hemopoietic Cells, Apoptosis, Tumor Cells, Acute Myeloblastic
Leukemia, Cytotoxicity, Granulopoiesis, Angiogenesis, Endocrinological
Autoimmune Diseases, Neurogenesis, Embryogenesis, Oncogenesis, Infestation,
Adhesion. |
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| Secondary
Search |
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Macrophages, Neutrophils, Basophils, Eosinophils,
Endothelial Cells, Mast Cells, Pleiotropic Proteins, Cell-Cell Communication,
Pro- Inflammatory Cytokines, Anti-Inflammatory Cytokines, Autocrine Hormones,
Antigen Presenting Cell, GMCSF, Granulocyte-Macrophage Colony Stimulating
Factor, Chemotactic Factor, Innate Immunity, Adaptive Immunity, Growth Factor,
T-Killers, Antibody, Monocytes |
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| CATEGORY |
| Cytokines, Cell Signaling, Hematopoiesis, Immunology |
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| Below is a list of IMGENEX antibodies against cytokines,
chemokines and their receptors. |
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1 |
2 | 3 |
4 | 5 | 6 | 7 | 8 | 9 | A |
B |
C |
D |
E |
F |
G |
H |
I |
J |
K |
L |
M |
N |
O |
P |
Q |
R |
S |
T |
U |
V |
W |
X |
Y |
Z |
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| Found 202 results, displaying 1 to 50 | Show all |
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| Cat.No |
Description |
Format |
Species |
Clone |
Application |
Publications |
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| IMG-206E |
IL-4 |
Azide-Free |
H |
4D9 |
FA (N), IF/ICC, WB |
 |
pricing
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| IMG-504 |
Asb-11 |
Purified |
H |
N/A |
WB |
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pricing
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| IMG-502 |
Asb-2 |
Sera |
H |
N/A |
WB |
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pricing
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| IMG-5553-1 |
BAFF-R (CT) |
Purified, Peptide Affinity |
H, M, R |
N/A |
IHC (p), WB |
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pricing
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| IMG-5553-2 |
BAFF-R (CT) |
Purified, Peptide Affinity |
H, M, R |
N/A |
IHC (p), WB |
|
pricing
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| IMG-5591-1 |
Bonzo (CT) |
Purified |
H |
N/A |
WB |
|
pricing
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| IMG-5591-2 |
Bonzo (CT) |
Purified |
H |
N/A |
WB |
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pricing
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| IMG-5430-1 |
Bonzo (NT2) |
Purified, Peptide Affinity |
H |
N/A |
WB |
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pricing
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| IMG-5430-2 |
Bonzo (NT2) |
Purified, Peptide Affinity |
H |
N/A |
WB |
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pricing
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| IMG-72169 |
C-C Chemokine Receptor 3 (CCR3) |
Purified, Peptide Affinity |
H |
N/A |
IHC (p) |
 |
pricing
|
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| IMG-5008 |
CAMK 1D-b |
Purified |
H |
N/A |
WB |
|
pricing
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| IMG-329 |
CCR1 (C-C Chemokine Receptor 1)/CD191 |
Purified |
H, M |
N/A |
Flow (CS), WB |
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pricing
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| IMG-286 |
CCR10 (C-C Chemokine Receptor 10) |
Purified |
H |
N/A |
Flow (I), IHC (frozen), WB |
 |
pricing
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| IMG-331A |
CCR3 (C-C Chemokine Receptor 3) |
Purified |
H, M, R |
N/A |
WB |
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pricing
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| IMG-331E |
CCR3 (C-C Chemokine Receptor 3) |
Purified |
H, M, R |
N/A |
WB |
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pricing
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| IMG-332 |
CCR4 (C-C Chemokine Receptor 4)/CD194 |
Purified |
H, M, R |
N/A |
WB |
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pricing
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| IMG-333 |
CCR5 (C-C Chemokine Receptor 5) |
Purified |
H |
N/A |
WB |
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pricing
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| DDX0700 |
CD127/IL-7R |
Purified |
H |
R34-34 |
FA (N), Flow (CS), IP |
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pricing
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| DDX0700A488 |
CD127/IL-7R |
Alexa Fluor® 488 |
H |
R34-34 |
Flow (CS) |
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pricing
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| DDX0700A546 |
CD127/IL-7R |
Alexa Fluor® 546 |
H |
R34-34 |
Flow (CS) |
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pricing
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| DDX0700A647 |
CD127/IL-7R |
Alexa Fluor® 647 |
H |
R34-34 |
Flow (CS) |
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pricing
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| DDX0700-50 |
CD127/IL-7R |
Purified |
H |
R34-34 |
FA (N), Flow (CS), IP |
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pricing
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| DDX0700A546-50 |
CD127/IL-7R |
Alexa Fluor® 546 |
H |
R34-34 |
Flow (CS) |
|
pricing
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| DDX0700A488-50 |
CD127/IL-7R |
Alexa Fluor® 488 |
H |
R34-34 |
Flow (CS) |
|
pricing
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| DDX0700G-50 |
CD127/IL-7R |
APC |
H |
R34-34 |
Flow (CS) |
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pricing
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| DDX0700D-50 |
CD127/IL-7R |
PE |
H |
R34-34 |
Flow (CS) |
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pricing
|
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| IMG-5454-1 |
CTRP2 |
Purified, Peptide Affinity |
H, M, R |
N/A |
WB |
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pricing
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| IMG-5454-2 |
CTRP2 |
Purified, Peptide Affinity |
H, M, R |
N/A |
WB |
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pricing
|
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| IMG-5463-1 |
CTRP7 |
Purified, Peptide Affinity |
H, M, R |
N/A |
WB |
|
pricing
|
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| IMG-5463-2 |
CTRP7 |
Purified, Peptide Affinity |
H, M, R |
N/A |
WB |
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pricing
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| IMG-5461-1 |
CTRP7 (CT) |
Purified, Peptide Affinity |
H, M, R |
N/A |
WB |
|
pricing
|
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| IMG-5461-2 |
CTRP7 (CT) |
Purified, Peptide Affinity |
H, M, R |
N/A |
WB |
|
pricing
|
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| IMG-183-1 |
CX3CR1 |
Purified |
H, M, R |
N/A |
IHC (p), WB |
|
pricing
|
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| IMG-183-2 |
CX3CR1 |
Purified |
H, M, R |
N/A |
IHC (p), WB |
|
pricing
|
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| IMG-5464-1 |
CX3CR1 (EL) |
Purified, Peptide Affinity |
H |
N/A |
WB |
|
pricing
|
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| IMG-5464-2 |
CX3CR1 (EL) |
Purified, Peptide Affinity |
H |
N/A |
WB |
|
pricing
|
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| IMG-334 |
CXCR1 (CXC Chemokine Receptor 1)/IL-8R A |
Purified |
H |
N/A |
WB |
|
pricing
|
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| IMX-6202 |
CXCR3 (CXC Chemokine Receptor 3) |
Sera |
H |
N/A |
Peptide ELISA |
|
pricing
|
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| IMG-537 |
CXCR4 (CXC Chemokine Receptor 4) |
Purified |
H, M, R, Sh |
N/A |
IHC (cryosections), IHC (p), WB |
|
pricing
|
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| IMG-126-1 |
CXCR4 (CXC Chemokine Receptor 4) |
Purified |
H, M |
N/A |
WB |
|
pricing
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| IMG-126-2 |
CXCR4 (CXC Chemokine Receptor 4) |
Purified |
H, M |
N/A |
WB |
|
pricing
|
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| IMG-125-1 |
CXCR4 (CXC Chemokine Receptor 4) (NT) |
Purified |
H, M |
N/A |
IF/ICC, WB |
|
pricing
|
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| IMG-125-2 |
CXCR4 (CXC Chemokine Receptor 4) (NT) |
Purified |
H, M |
N/A |
IF/ICC, WB |
|
pricing
|
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| IMG-327 |
CXCR5 (CXC Chemokine Receptor 5) |
Purified |
H |
N/A |
WB |
|
pricing
|
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| IMG-6327A |
EBI3 |
Purified, Peptide Affinity |
H, M, R |
N/A |
IHC (p), WB |
|
pricing
|
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| IMG-6706A |
EBI3 |
Purified |
M |
IMG10J706 |
Flow (I), WB |
|
pricing
|
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| IMG-6707A |
EBI3 |
Purified |
M |
IMG10J763 |
Flow (I), WB |
|
pricing
|
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| IMG-6708A |
EBI3 |
Purified |
M |
IMG10J803 |
Flow (I), WB |
|
pricing
|
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| IMG-6709A |
EBI3 |
Purified |
M |
IMG10J811 |
Flow (I), WB |
|
pricing
|
|
| IMG-6832A |
EBI3 |
Purified |
H |
IMG42N1G4 |
Flow (I), WB |
|
pricing
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