MyD88 is a major adaptor molecule involved in TLR, IL-1 and IFNg signaling pathways. Cell activation through TLRs leads to MyD88 mediation of NF-kB as well as Erk, Jnk and p38 signaling pathways involved in inflammatory mediator gene transcription. IFNg activation of MyD88 leads to p38 activation and downstream regulation of TNF and IP-10 transcripts.
 
The MyD88 specific monoclonal antibody (4D6), along with our other adaptor molecule reagents specific to TRIF, TIRAP, SARM and TRAM, enable development of assays, read-out systems and potential target development for cell signaling, control especially for Western Blot, Flow Cytometry or IHC applications.

IMGENEX features an extensive portfolio of antibodies, reagents, kits, cell lines and peptide inhibitors for studying NF-kB related signaling pathways closely linked to TLR, Immune or Inflammatory signaling pathways.