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Monoclonal Antibody to CD20 (mAb75) |
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| Catalog No: |
DDX0110-50 |
| Contents: |
Antibody in Tris-NaCl pH 8 |
| Isotype: |
IgM |
| Clone: |
mAb75 |
| Purification: |
QMA Hyper D ion exchange chromatography) |
| Species: |
Human |
| Host: |
Mouse |
| Supplier: |
Dendritics |
| Market Availability: |
North America (United States & Canada) |
| Application: |
Flow: |
| Storage: |
Aliquot and store at -20°C, protected from light. Contains no preservative; KEEP STERILE; AVOID REPEATED FREEZE/THAW CYCLES. |
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Background
A monoclonal antibody mAb75 has been generated which binds to germinal center B cells but not to naïve / memory cells. It also binds to some Burkitt’s lymphomas and to all Hairy cell leukemias tested. The CD20 epitope recognized by mAb75 became detectable on naïve B cells in response to TNF-?/? and/or IL10. Interestingly IL4, IFNs and TGF? are strong antagonists to mAb75 epitope induction. Ligation of mAb75 epitope was found to enhance B cell growth. (Meffre G. et al, unpublished data) |
Antigen
human tonsil germinal center B cells |
Application Notes
*This monoclonal antibody may be used between 5-20 ug/ml. |
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Induction by:IL10 + TNF a/b |
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Inhibition by:IL1a/b, IL2, IL3, IL4, IL5, IL7, TGFb, IFN a/g, IL12 |
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Reference
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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