Background
Using a cDNA subtraction technique, a novel member of the immunoglobulin superfamily was isolated from human dendritic cells (DCs). This cDNA which is named DORA, for Down-Regulated by Activation encodes a protein belonging to the CD8 family of receptors containing a single V type loop domain with an associated J chain region, a transmembrane region containing an atypical tyrosine residue and a cytoplasmic domain containing three putative tyrosine phosphorylation sites. The human DORA gene has been localized to chromosome 16. Expression is observed in DCs, purified ex vivo or generated in vitro from either monocytes or CD34+ progenitors, and down-regulated following activation by PMA and Ionomycin or by CD40L engagement. Bates EE et al., 2000 Immunogenetics, 52: 112-20) (Bates EE et al., 1998 Molecular Immunology, 35: 513-24) |
Reference
1. Bates EE et al., 2000 Immunogenetics, 52:112-20
2. Bates EE et al., 1998 Molecular Immunology, 35:513-24
|
