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Monoclonal Antibody to CD207/Langerin (Clone 205C1) Alexa 546 Conjugated |
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| Catalog No: |
DDX0370A546-50 |
| Contents: |
Antibody in PBS 50% glycerol |
| Isotype: |
IgM |
| Clone: |
205C1 |
| Purification: |
Purified using a QMA Hyper D ion exchange column |
| Species: |
Mouse |
| Host: |
Mouse |
| Supplier: |
Dendritics |
| Market Availability: |
North America (United States & Canada) |
| Application: |
IF/ICC: 5-20 ug/ml* |
| Storage: |
Aliquot and store at -20°C, protected from light. Contains no preservative; KEEP STERILE; AVOID REPEATED FREEZE/THAW CYCLES. |
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Background
Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. |
Antigen
Mouse ear crawl-out Langerhans cells |
Application Notes
Optimal dilution should be determined by each laboratory for each application |
| Genebank Info (Protein): NP_056532 |
| Gene ID: 50489 |
| SwissProt: Q9UJ71 |
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Freshly isolated epidermal murine Langerhans cells: FACS analysis using 205C1. |
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Reference
1. Valladeau J et al, 2002 J Immunol, 168 : 782-792
2. Douillard P et al, 2005 J Invest Dermatol, 125: 983–994
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Research purposes only.
Not for diagnostic or in vivo use.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc. IMGENEX sells Alexa Fluor® dye conjugated antibodies under license from Molecular Probes, Inc. for research use only.
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