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Product : Antibody >> TNF Family & Death Re.. >> DR3 (NT)
      
 

Polyclonal Antibody to DR3

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-106-1
DR3 (NT)Purified
0.05 mg
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Catalog No: IMG-106-1
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Contents: 0.05 mg of purified antibody in PBS containing 0.02% sodium azide.
Isotype: Rabbit Ig
Clone: N/A
Purification: Protein G Chromatography
Species: Human
Host: Rabbit
Application: Western blot analysis: 1:500-1:1000
Storage: Store at 4C.
Recommended
Positive Control:
Jurkat
 

Background
Apoptosis or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD (1-5). The ligand for this novel cell death receptor has not yet been defined. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kB activation.

Antigen
Rabbit anti-DR3 (NT) polyclonal antibody was raised against a peptide corresponding to amino acid 25 to 40 at N-terminus of human DR3 (1,2).

Application Notes
A59 kDa band should be observed. Since the ligand for DR3 has not been found, this antibody may be useful for receptor engagement to perform function studies of this novel death receptor.

Genebank Info (Protein): NP_042997
 
DR3 (NT) Antibody

Western blot analysis of 10 g of total cell lysate from Jurkat cells with anti-DR3 (NT) at 1:1000 dilution.

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Reference
1. Marsters SA; Sheridan JP; Donahue CJ; Pitti RM; Gray CL; Goddard AD; Bauer KD; Ashkenazi A. Curr Biol, 1996;6:1669-76.
2. Bodmer JL; Burns K; Schneider P; Hofmann K; Steiner V; Thome M; Bornand T; Hahne M; Schroter M; Becker K; et al. Immunity, 1997;6:79-88.
3. Screaton GR; Xu XN; Olsen AL; Cowper AE; Tan R; McMichael AJ; Bell JI. Proc. Nat. Acad. Sci. USA. 1997;94:4615-9
4. Chinnaiyan AM; O'Rourke K; Yu GL; Lyons RH; Garg M; Duan DR; Xing L; Gentz R; Ni J; Dixit VM. Science, 1996;274:990-2.
5. Kitson J; Raven T; Jiang YP; Goeddel DV; Giles KM; Pun KT; Grinham CJ; Brown R; Farrow SN. Nature, 1996;384:372-5.


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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