Polyclonal Antibody to DR3/Wsl-1/Apo-3/TRAMP/LARD1-5

Background
Apoptosis or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD (1-5). The ligand for this novel cell death receptor has not yet been defined. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kB activation.

Antigen
Rabbit anti-DR3 (CT) polyclonal antibody was raised against a peptide corresponding to amino acid 25 to 40 at N-terminus of human DR3 (1,2).

Application Notes
A 59 kDa band should be observed. Since the ligand for DR3 has not been found, this antibody may be useful for receptor engagement to perform function studies of this novel death receptor.

Genebank Info (Protein)
NP_042997

Reference
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