PATHWAY PROFILING ANTIBODIES & REAGENTS

     
Products
Product : Antibody >> Cancer Antibodies , TNF Family & Death Re.. >> DR4/TRAILR1 (CT)
      
 

Polyclonal Antibody to DR4/TRAILR1 (CT)

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-108-2
DR4/TRAILR1 (CT)Purified
0.1 mg
 --
 
Catalog No: IMG-108-2
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.1 mg g in 0.2 ml PBS containing 0.02% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit Ig
Clone: N/A
Purification: Protein G Chromatography
Species: Human
Host: Rabbit
Application: Western blot analysis: 1:500-1:1000
Storage: Store at 4C.
Recommended
Positive Control:
HeLa
 

Background
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4) (1). The ligand for this novel death receptor has been identified and termed TRAIL (2), which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1) (3). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NFkB activation in many tissues and cells.

Antigen
Rabbit anti-DR4 (CT) polyclonal antibody was raised against a peptide corresponding to amino acid 427 to 445 of human DR4 mature protein.

Application Notes
A57 KDa band should be observed.

Genebank Info (Protein): NP_042998
 
DR4/TRAILR1 (CT) Antibody

Western blot analysis of 50 g of total cell lysate from HeLa cells with anti-DR4 (CT) at 1:500 dilution.

-

Reference
1. Pan G; O'Rourke K; Chinnaiyan AM; O'Rourke K; Gentz R; Ebner R; Ni J; Dixit VM. The receptor for the cytotoxic ligand TRAIL. Science; 1997; 276:111-113.
2. Pitti RM; Marsters SA; Ruppert S; Donahue CJ; Moore A; Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 1996; 271:12687-90.
3. Schneider P, Thome M, Burns K, Bodmer JL, Hofmann K, Kataoka T, Holler N, Tschopp J. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-B. Immunity 1997; 7:831-836.


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


Products

Services

Resources

Purchasing

Company

  • What's New
  • Reporter Cells
  • Screening Services
  • Interactive Pathways