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Product : Antibody >> TNF Family & Death Re.. >> DR5/TRAILR2
      
 

Polyclonal Antibody to DR5/Apo2/TRAIL-R2/TRAILR2/TRICK2/KILLER

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-120E
DR5/TRAILR2Azide-Free
0.1 mg
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Catalog No: IMG-120E
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions – novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.1 mg in 0.2 ml filter-sterilized PBS. Sodium azide free.
Isotype: Rabbit IgG
Purification: Protein G Chromatography
Species: Human
Host: Rabbit
Application: Flow (Cell Surface): As reported in KOYAMA (2003)
IF/ICC: As reported in Georgakis et al. (2005)
IHC (paraffin): As reported in Younes et al. (2006)
Western blot analysis: 5 ug/ml
Storage: Aliquot and store frozen at -20°C.
Recommended
Positive Control:
HL60 or Jurkat
 

Background
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-2). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

Antigen
Rabbit anti-DR5 polyclonal antibody was raised against a peptide corresponding to amino acids 388 to 407 (isoform 2) of human DR5 precursor (1,2). The same sequence is found in isoform 1 at amino acids 417-436.

Application Notes
**Please note that this product is now being supplied at 0.5 mg/ml.

Genebank Info (Protein): NP_042999
 
DR5/TRAILR2 Antibody

Western blot analysis of 20 µg of whole cell lysates from HL60 cells with anti-DR5 at 5 ug/ml.

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Reference
1. Pan G, Ni J, Wei YF, Yu G, Gentz R, Dixit VM. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997;277:815-8
2. Sheridan JP, Marsters SA, Pitti RM, Gurney A, Skubatch M, Baldwin D, Ramakrishnan L, Gray CL, Baker K, Wood WI, Goddard AD, Godowski P, Ashkenazi A. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 1997;277:818-21


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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