Polyclonal Antibody to DcR2/ TRAIL-R4/ TRUNDD

Background
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL/R4, or TRUNDD (2). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.

Antigen
Rabbit anti-DcR2 polyclonal antibody was raised against a peptide corresponding to amino acids 249 to 263 of human DcR2 precursor (2).

Application Notes
A band of approximate molecular weight 35 kD will be detected.

Genebank Info (Protein)
NP_003831

Reference
1. Pan G, O’Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM. The receptor for the cytotoxic ligand TRAIL. Science 1997;276:111-113.
2. Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenayi A. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol 1997; 7:1003-1006.