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Product : Antibody >> TNF Family & Death Re.. >> DcR2
      
 

Polyclonal Antibody to DcR2/ TRAIL-R4/ TRUNDD

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-121-2
DcR2Purified
0.1 mg
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Catalog No: IMG-121-2
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions – novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.1 mg in 0.2 ml PBS containing 0.02% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit Ig
Clone: N/A
Purification: Protein G Chromatography
Species: Human
Host: Rabbit
Application: Flow (Cell Surface): See Anderson et al (2002).
Western blot analysis: 1:1000 to 1:2000
Storage: Store at 4°C.
Recommended
Positive Control:
HeLa
 

Background
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL/R4, or TRUNDD (2). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.

Antigen
Rabbit anti-DcR2 polyclonal antibody was raised against a peptide corresponding to amino acids 249 to 263 of human DcR2 precursor (2).

Application Notes
A band of approximate molecular weight 35 kD will be detected.

Genebank Info (Protein): NP_003831
Gene ID: 8793
SwissProt: Q9UBN6
 
DcR2 Antibody

Western blot analysis of 50 µg of whole cell lysate from HeLa cells with anti-DcR2 at 1:1000 dilution.

DcR2 Antibody IMG-121-2

Immunohistochemical staining of HeLa cells using anti-DcR2 (ID) at 10µg/ml.

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Reference
1. Pan G, O’Rourke K, Chinnaiyan AM, Gentz R, Ebner R, Ni J, Dixit VM. The receptor for the cytotoxic ligand TRAIL. Science 1997;276:111-113.
2. Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenayi A. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol 1997; 7:1003-1006.


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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