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Product : Antibody >> TNF Family & Death Re.. >> DR6
      
 

Polyclonal Antibody to DR6

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-166
DR6Purified
0.1 mg
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Catalog No: IMG-166
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.1 mg in 0.2 ml PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit Ig
Clone: N/A
Purification: Protein G Chromatography
Species: Human
Host: Rabbit
Application: Western blot analysis: 2-4 ug/ml
Storage: Store at 4C. For long-term storage, store at -20C.
Recommended
Positive Control:
Daudi, HeLa, or Jurkat
 

Background
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR6 (for death receptor 6) (1). The extracellular domain of DR6 contains four TNFR-like cysteine rich motifs that are related to those of osteoprotegerin (OPG) (2) and TNFR2 (3) with 36% and 42% amino acid identities, respectively. The death domain of DR6 (amino acids 428-494) located adjacent to the transmembrane domain is most related to TNFR1 (27.2%) and least to DR5 (19.7%) (1).

Antigen
The antibody was raised against the cytoplasmic domain (amino acids 371-655) of human DR6 protein.

Application Notes
A ~66 kDa band is observed.

Genebank Info (Protein): NP_043000
Gene ID: 1487974
 
DR6 Antibody

Western blot analysis of 30 g of total cell lysate from Jurkat (lane 1), HeLa (lane 2), and Daudi (lane 3) cells with IMG-166 at 2 g/ml.

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Reference
1. Pan, G., Bauer, J.H., Haridas, V., Wang, S., Liu, D., Yu, G., Vincenz, C., Aggarwal, B., Ni, J. and Dixit, V.M. FEBS Lett. 431: 351-356 (1998).
2. Simonet WS, Lacey DL, Dunstan CR, Kelley M. et al. Cell 89: 309-310 (1997).
3. Baker, S.J. and Reddy, E.P. Oncogene 12: 1-9 (1996).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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