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Product : Antibody >> TNF Family & Death Re.. >> TACE 
      
 

Polyclonal Antibody to TACE/ADAM17

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-176-1
TACE Purified
0.05 mg
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Catalog No: IMG-176-1
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions – novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.05 mg of purified antibody in PBS containing 0.02% sodium azide.
Isotype: Rabbit Ig
Clone: N/A 
Purification: Protein G Chromatography
Species: Human, Mouse, Rat
Host: Rabbit
Application: Western blot analysis: 1-3 ug/ml 
Storage: Store at 4°C.
Recommended
Positive Control:
HeLa or Jurkat
 

Background
Membrane-bound form of TNF-a is cleaved by a convertase to generate a secreted 17 kD mature protein. TNF-a converting enzyme, TACE, is a membrane bound metalloprotease-disintegrin. It also processes other cell surface proteins, including TNF receptor, TGFa, and alpha cleavage of amyloid protein precursor.

Antigen
The polyclonal antibody was raised against a peptide corresponding to amino acids 807 to 823 of human TACE. This sequence differs from those of mouse and rat TACE by one amino acid.

Application Notes
80 to 130 kDa bands are observed, which may represent mature protein, precursor, and glycosylated TACE.

Genebank Info (Protein): NP_003174
Gene ID: 6868
 
TACE  Antibody

Western blot analysis for TACE using IMG-176 at 1 µg/ml against 10 µg/lane of HeLa (lane 1&3) and Jurkat (lane 2&4) cell lysates in the absence (lane 1&2) and presence (lane 3&4) of blocking peptide.

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Reference
1. Black RA, et al. Nature 385: 729-733 (1997).
2. Moss ML, et al. Nature 385: 733-736 (1997).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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