Product : Antibody >> TNF Family & Death Re.. >> DcR1

Polyclonal Antibody to DcR1 (TRAIL-R3, TRID, LIT)

Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
0.1 mg
Catalog No: IMG-245-2
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 ug in 200 ul PBS containing 0.02% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit IgG
Clone: N/A
Purification: Protein G Chromatography
Species: Human
Host: Rabbit
Application: Western blot analysis: 1 ug/ml
Storage: Store at 4C.
Positive Control:
293 or HeLa
Product Citations
1. Activation of nuclear factor-kB contributes to induction of death receptors nuclear and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Jin F, X Liu, Z Zhou, P Yue, R Lotan, FR Khuri, LWK Chung, S-Y Sun. Cancer Res 65:6354-6363 (2005).
IMGENEX antibodies cited for WB:
1. Caspase-3 mAb, clone 31A1067 (IMG-144A): Fig 3C, DU145 prostate adenocarcinoma cells.
2. DcR1 pAb (IMG-245-1/IMG-245-2): Fig 6C, DcR1 overexpressing DU145 cells.
Note: The specificity of the DcR1 pAb was validated in DcR1 overexpressing DU145 cells by WB in Fig 6C.
3. DR4 mAb, clone 32A242 (IMG-275): Figs 5 and 6B, DU145 cells. 
4. TRAIL mAb, clone 55B709.3 (IMG-256A): Fig 6B, recombinant human TRAIL protein.
note: The specificity of the TRAIL mAb was validated using recombinant human TRAIL protein by WB in Fig 6B.
2. Cathepsin E prevents tumor growth and metastiasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface. Kawakubo T, K Okamoto, J Iwata, M Shin, Y Okamoto, A Yasukochi, K Nakayama, T Kadowaki, T Tsukuba, K Tamamoto. Cancer Research 67: 10869-10878 (2007). Imgenex products cited:
1. IMG-121 (DcR2): WB (human prostate carcinoma cell lines), Fig. 4B.
2. IMG-245 (DcR1): WB (human prostate carcinoma cell lines), Fig. 4B.
3. Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells.  Taniguchi H, T Yoshida, M Horinaka, T Yasuda, AE Goda, M Konishi, M Wakada, K Kataoka, T Yoshikawa and T Sakai. Cancer Research 68: 8918-8927 (2008). Imgenex products cited:
1. IMG-121 (DcR2): WB (human colon carcinoma SW480 cell line), Fig 3.
2. IMG-245 (DcR1): WB (human colon carcinoma SW480 cell line), Fig 3.
4. Predominant antitumor effects by fully human anti-TRAIL-receptor2 (DR5) monoclonal antibodies in human glioma cells in vitro and in vivo. Nagane M, S Shimizu, E Mori, S Kataoka, Y Shiokawa. Neuro-Onc doi: 10.1093/neuonc/nop069 (2010). IMGENEX products cited:
1. DcR2 (IMG-121-1): WB (human glioma cell lines), Fig 4B.
2. DcR1 (IMG-245-1): WB (human glioma cell lines), Fig 4B.






  • What's New
  • Reporter Cells
  • Screening Services
  • Interactive Pathways