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Polyclonal Antibody to DcR1 (TRAIL-R3, TRID, LIT) |
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| Catalog No: |
IMG-245-2 |
| Contents: |
100 ug in 200 ul PBS containing 0.02% sodium azide. Sodium azide is highly toxic. |
| Isotype: |
Rabbit IgG |
| Clone: |
N/A |
| Purification: |
Protein G Chromatography |
| Species: |
Human |
| Host: |
Rabbit |
| Application: |
Western blot analysis: 1 ug/ml
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| Storage: |
Store at 4°C. |
Recommended
Positive Control: |
293 or HeLa |
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| Product Citations |
1. Activation of nuclear factor-kB contributes to induction of death receptors nuclear and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Jin F, X Liu, Z Zhou, P Yue, R Lotan, FR Khuri, LWK Chung, S-Y Sun. Cancer Res 65:6354-6363 (2005).
IMGENEX antibodies cited for WB:
1. Caspase-3 mAb, clone 31A1067 (IMG-144A): Fig 3C, DU145 prostate adenocarcinoma cells.
2. DcR1 pAb (IMG-245-1/IMG-245-2): Fig 6C, DcR1 overexpressing DU145 cells.
Note: The specificity of the DcR1 pAb was validated in DcR1 overexpressing DU145 cells by WB in Fig 6C.
3. DR4 mAb, clone 32A242 (IMG-275): Figs 5 and 6B, DU145 cells.
4. TRAIL mAb, clone 55B709.3 (IMG-256A): Fig 6B, recombinant human TRAIL protein.
note: The specificity of the TRAIL mAb was validated using recombinant human TRAIL protein by WB in Fig 6B. | 2. Cathepsin E prevents tumor growth and metastiasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface. Kawakubo T, K Okamoto, J Iwata, M Shin, Y Okamoto, A Yasukochi, K Nakayama, T Kadowaki, T Tsukuba, K Tamamoto. Cancer Research 67: 10869-10878 (2007). Imgenex products cited:
1. IMG-121 (DcR2): WB (human prostate carcinoma cell lines), Fig. 4B.
2. IMG-245 (DcR1): WB (human prostate carcinoma cell lines), Fig. 4B. | 3. Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells. Taniguchi H, T Yoshida, M Horinaka, T Yasuda, AE Goda, M Konishi, M Wakada, K Kataoka, T Yoshikawa and T Sakai. Cancer Research 68: 8918-8927 (2008). Imgenex products cited:
1. IMG-121 (DcR2): WB (human colon carcinoma SW480 cell line), Fig 3.
2. IMG-245 (DcR1): WB (human colon carcinoma SW480 cell line), Fig 3. | 4. Predominant antitumor effects by fully human anti-TRAIL-receptor2 (DR5) monoclonal antibodies in human glioma cells in vitro and in vivo. Nagane M, S Shimizu, E Mori, S Kataoka, Y Shiokawa. Neuro-Onc doi: 10.1093/neuonc/nop069 (2010). IMGENEX products cited:
1. DcR2 (IMG-121-1): WB (human glioma cell lines), Fig 4B.
2. DcR1 (IMG-245-1): WB (human glioma cell lines), Fig 4B. |
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