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Product : Antibody >> TNF Family & Death Re.. >> TACI
      
 

Polyclonal Antibody to TACI (Transmembrane Activator and CAML Interactor)

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-249
TACIPurified
0.1 mg
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Catalog No: IMG-249
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.1 mg in 0.2 ml PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit Ig
Clone: N/A
Purification: Protein G Chromatography
Species: Human, Mouse
Host: Rabbit
Application: Western blot analysis: 0.5-2 ug/ml
Storage: Store at 4C, stable for 6 months. For long-term storage, store at -20C.
 

Background
Simultaneously four different laboratories identified a a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 (1), THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase (2), BAFF (for B cell activating factor belonging to the TNF family) (3) and BlyS (B lymphocyte stimulator) (4). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The receptor for BlyS/BAFF appears to be expressed predominantly on B cells and activated T cells (5). Recently two orphan receptors TACI (6) and BCMA (,8) have been shown to be receptors for BlyS/BAFF (6-9). TACI is expressed on B cells and signals through CAML, activating the transcription factors NF-AT, NF-kB, and AP-1. TACI is a type III transmembrane protein, as defined by the lack of a cleaved signal sequence and its N-terminal extracellular exposure. The cDNA codes for 293 amino acids with predicted molecular weight of approximately 32 kDa.

Antigen
This rabbit polyclonal antibody was developed against a synthetic peptide corresponding to amino acids 116-132 of human TACI. Human and mouse TACI amino acid sequences are 65% conserved in the immunogen.

Genebank Info (Protein): NP_036584
Gene ID: 23495
 
TACI Antibody IMG-249

Western blot analysis of A) human spleen, B) mouse spleen, C) human stomach, D) and mouse stomach lysate using TACI antibody at 2 ug/ml.

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Reference
1. Shu HB, Hu WH, Johnson H J Leukoc Biol 65(5): 680-683 (1999).
2. Mukhopadhyay A, Ni J, Zhai Y, Yu GL, Aggarwal BB. J Biol Chem 274(23): 15978-15981 (1999).
3. Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, et al. J Exp Med 189(11): 1747-1756 (1999).
4. Moore PA, Belvedere O, Orr A, Pieri K, LaFleur DW, Feng P, Soppet D, Charters M, Gentz R, Parmelee D, Li Y, Galperina O, et al. Science 285 (5425):260-3 (1999).
5. von Buelow GU and Bram RJ. Science 278: 138-141 (1997).
6. von Buelow GU, Russell H, Copeland NG, Gilbert DJ, Jenkins NA, Bram RJ. Mamm Genome 11: 628-632 (2000).
7. Laabi Y., et al. EMBO J 11: 3897-3904 (1992).
8. Gras M-P, et al. Int. Immunol 7: 1093-1106 (1995).
9. Marsters SA, Yan M, Pitti RM, Haas PE, Dixit VM, Ashkenazi A. Curr Biol 10(13): 785-788 (2000).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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