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Product : Antibody >> Chromatin , DNA Methylation & Rep.. >> Dnmt3a
      
 

Monoclonal Antibody to Dnmt (DNA methyltransferase) 3a Biotin Conjugate

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-266B
Dnmt3aBiotin
0.1 mg
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Catalog No: IMG-266B
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 g in 200 l PBS containing 0.05% sodium azide. Sodium azide is highly toxic.
Isotype: Mouse-IgG1
Clone: 64B814.1
Purification: Protein G Chromatography
Species: Human, Mouse
Host: Mouse
Application:
Storage: Store at 4oC, stable for 6 months. Do not freeze.
 

Background
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of Dnmt3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.

Antigen
This antibody was raised against bacteria expressed recombinant mouse Dnmt3a.

Genebank Info (Protein): NP_715640
Gene ID: 1788
SwissProt: Q9Y6K1
 
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Reference
1. Xie S, Wang Z, Okano M, Nogami M, Li Y, He WW,      Okumura K, and Li E. Gene 236: 87-95 (1999).
2. Okano M, Bell DW, Haber DA,a nd Li E. Cell 99: 247-    257 (1999).
3. Reik W, Kelsey G, and Walter J. Nat. Genet 23: 380-382     (1999).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for six months from the date of purchase.


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