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Product : Antibody >> Apoptosis , Cancer Antibodies , Cytokine & Chemokine , Signal Transduction , TNF Family & Death Re.. >> STAT2
      
 

Polyclonal Antibody to STAT2

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-291
STAT2Purified
0.1 mg
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Catalog No: IMG-291
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit IgG
Purification: Protein G Chromatography
Species: Human
Host: Rabbit
Application: Western blot analysis: 3-5 ug/ml
Storage: Aliquot and store at -20C.
Recommended
Positive Control:
Jurkat
 

Background
STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5a, and Stat5b have a wide activation profile (4,5). Human Stat2 cDNA codes for a 851 amino acid protein with a predicted molecular weight of 113 kDa (3). STAT2 associates with beta subunit of the type I IFN receptor in an interferon-dependent manner (1-3).

Antigen
This polyclonal antibody was developed against a synthetic peptide corresponding to amino acids 830-849 of human STAT2.

Application Notes

Genebank Info (Protein): NP_005410
Gene ID: 6773
 
STAT2 Antibody

Western blot analysis of STAT2in Jurkat cell lysate using IMG-291 at 3 ug/ml.

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Reference
1. Leonard WJ, O'Shea JJ. Jaks and STATs: biological implications. Annu Rev Immunol 16:293-322 (1998).
2. Schindler C, Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 64:621-51 (1995).
3. Bluyssen HA and Levy DE. J Biol Chem 272: 4600-4605 (1997).
4. Darnell JE Jr. STATs and gene regulation. Science 277:1630-1635 (1997).
5. Uddin S, Chamdin A, Platanias LC J Biol Chem 20; 270(42): 24627-305 (1995).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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