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Product : Antibody >> Antigen Affinity Purified , Apoptosis , Chromatin , DNA Fragmentation >> AIF (IN)
      
 

Polyclonal Antibody to AIF (IN)

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-303-2
AIF (IN)Purified
0.1 mg
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Catalog No: IMG-303-2
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions – novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.1 mg in 0.2 ml PBS containing 0.02% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit IgG
Clone: N/A
Purification: Protein G Chromatography
Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC (paraffin): 0.25 to 1 µg/ml
Western blot analysis: 0.5 ug/ml
Storage: Store at 4°C.
Recommended
Positive Control:
human, mouse, rat heart lysate, or K562 cell lysate
 

Background
Apoptosis-inducing factor (AIF) is a phylogenetically ancient mitochondrial intermembrane flavoprotein. AIF induces caspase-independent peripheral chromatin condensation and large-scale DNA fragmentation when added to purified nuclei. Upon apoptosis induction AIF translocates to the cytosol and the nucleus.

Antigen
This antibody was generated by immunizing rabbits with synthetic peptides of human AIF.

Application Notes
A 65 kDa band is observed.

Genebank Info (Protein): NP_001124319
Gene ID: 9131
SwissProt: O95831
 
AIF (IN) Antibody

Detection of AIF (IN) in human (lane 1) mouse (lane 2) and rat (lane 3) heart using IMG-303 at 0.5 ug/ml.

AIF (IN) Antibody IMG-303-2

IHC analysis of AIF in human retina using IMG-303 at 10 ug/ml.

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Reference
1. Marzo I. et al.  FEBS Lett 427(2):198-202 (1998).
2. Susin S.A., et al. Nature. Feb 4;397(6718):441-6 (1999).
3. Cande C., et al. Biochimie 84(2-3):215-222 (2002).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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