PATHWAY PROFILING ANTIBODIES & REAGENTS

     
Products
Product : Antibody >> Cytokine & Chemokine , Th17 Antibodies >> IL-17E (IL-25)
      
 

Monoclonal Antibody against Human IL-17E (IL-25)

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-323A
IL-17E (IL-25)Purified
0.1 mg
 --
 
Catalog No: IMG-323A
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions – novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 µg of IL-17E antibody in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype: Mouse IgG1
Clone: 68C1039.2
Purification: Protein G Chromatography
Species: Human, Mouse
Host: Mouse
Application: Western blot analysis: use antibody at 2-4 ug/ml
Storage: Store IL-17E antibdoy at 4°C, stable for 6 months. For long-term storage, store antibody at –20°C.
 

Background
A number of cytokines belonging to the interleukin (IL)-17 family have been identified, termed IL-17A-F.  IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis (3), multiple sclerosis (4), and promotion of tumor growth (5). IL-17E, C, and B are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that an additional IL-17R related receptor may exist. Receptors for IL-17B and IL-17E have been independently isolated by Shi, et al (6) and Lee, et al. (2) and have been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E, also called IL-25, induces activation of NF-kB pathway and like IL-17 also induces production of IL-8.

Antigen
Amino acids 115-132 of human IL-17E (isoform CRA_a) were used as immunogen for this antibody.

Genebank Info (Protein): NP_758525
Gene ID: 64806
SwissProt: Q9H293
 
IL-17E (IL-25) Antibody

Western blot analysis of IL-17E using IL-17E monoclonal antibdody. Mouse testis lysate probed with IL-17E antibody at 2 ug/ml.

-

Reference
1. Tartour E, Fossiez F, Joyeux I, Galinha A, Gey A, et al. Cancer Res.59: 3698-3704 (1999).
2. Matusevicius D, Kivisakk P, He B, Kostulas N, Ozenci V, Fredrikson S, and Link H. Mult. Scler 5: 101-104 (1999).
3. Shalom-Barak T, Quach J, and Lotz M. J. Biol. Chem. 273: 27467-27473 (1998).
4. Lee J, Ho W-H, Maruoka M, Corpus RT, Baldwin DT, Fosters  JS, Goddard AD, Yansura DG, Vandlen RL, Wood WI, and Gurney AL. J. Biol. Chem. 276: 1660-1664 (2001).
5. Li H, Chen J, Huang A, Stinson J, Heldens S, Foster J, Dowd P, Gurney AL and wood WI. Proc. Natl. Acad. Sci., USA 97: 773-778 (2000).
6. Shi Y, Ulrich SJ, Zhang J, Connolly K., et al. J Biol. Chem. 275: 19167-19176 (2000).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


Products

Services

Resources

Purchasing

Company

  • What's New
  • Reporter Cells
  • Screening Services
  • Interactive Pathways