Background
Histones are relatively small proteins that contain a high proportion of positively charged amino acids, e.g., arginine and lysine. This positive charge allows histones to bind tightly to the negatively charged DNA. There are five basic types of histone molecules called H1, H2A, H2B, H3, and H4. Histones are abundantly present in virtually all eukaryotic cells. |
Reference
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2. Hengbin Wang, Liangjun Wang, Hediye Erdjument-Bromage, Miguel Vidal, Paul Tempst, Richard S. Jones & Yi Zhang. Role of histone H2A ubiquitination in Polycomb silencing. Nature 431, 873-878 (14 October 2004).
3. Yan Qing, Yanfang Liang, Qingqing Du, Pan Fan, Hangong Xu, Yiping Xu, Nian Shi. Apoptosis induced by Trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-κB and MAPKs signaling pathways. Archives of Toxicology February 2013
4. Mark Larance, Yasmeen Ahmad, Kathryn J. Kirkwood, Tony Ly and Angus I. Lamond. Global Subcellular Characterization of Protein Degradation Using Quantitative Proteomics. March 1, 2013 Molecular & Cellular Proteomics, 12, 638-650.
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