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Polyclonal Antibody to AXIN1 |
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| Catalog No: |
IMG-3597 |
| Contents: |
0.1 mg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Isotype: |
Goat Ig |
| Clone: |
N/A |
| Purification: |
Antigen Affinity Chromatography |
| Species: |
Human |
| Predicted React: |
Cow, Dog, Mouse, Rat |
| Host: |
Goat |
| Application: |
IHC (paraffin): 3-5µg/ml.
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| Storage: |
Store at -20°C. |
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Background
Principal Names: AXIN1; axin 1; AXIN; LA16c-314G4.3; MGC52315; axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; Official Symbol: AXIN1; Accession Number(s): NP_003493.1; NP_851393.1; Human GeneID(s): 8312; Non-Human GeneID(s): 12005 (mouse); 79257 (rat);Gene Ontology Terms: signal transducer activity; oocyte axis determination; frizzled receptor signaling pathway; development; apoptosis; cytoplasm; negative regulation of cell cycle; Important Comments: This antibody is expected to recognize both reported isoforms. |
Antigen
Peptide with sequence C-FEEKIIGKVEKVD, from the C Terminus of the protein sequence according to NP_003493.1; NP_851393.1. |
Application Notes
Immunohistochemistry: In paraffin embedded Human Adrenal Gland shows membranous and fibrous staniing in and around secretory cells of the zona fasciculata in the cortex. Recommended concentration, 3-5µg/ml. |
| Genebank Info (Protein): NP_003493.1, NP_851393.1 |
| Gene ID: 8312 |
| SwissProt: O15169 |
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IHC staining of AXIN1 in paraffin embedded Human Adrenal Cortex using IMG-3597 at 3.8µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. |
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Reference
1. Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL 3rd, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F.
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.
Cell. 1997 Jul 11;90(1):181-92.
PMID: 9230313
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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