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Product : Antibody >> Signal Transduction , Stem Cell Markers , Transcription Factors >> AML-1/RUNX1
      
 

Polyclonal Antibody AML-1

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-373
AML-1/RUNX1Purified
0.1 mg
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Catalog No: IMG-373
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions – novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 ug in 200 ul of PBS containing 0.2% gelatin, 0.05% sodium azide. Sodium azide is highly toxic
Isotype: Rabbit IgG
Clone: N/A
Purification: Protein G Chromatography
Species: Human, Mouse
Host: Rabbit
Application: Western blot analysis: 2-5 ug/ml
Storage: It is supplied as Protein G purified IgG. Store at 4°C, for long term store at –20°C.
Recommended
Positive Control:
Ramos, Raw
 

Background
AML-1 is a DNA-binding protein which specifically interacts with a sequence belonging to the group of enhancer core motifs, TGT/cGGT. The AML1 gene on chromosome 21 is disrupted in the (8;21)(q22;q22) translocation associated with acute myelogenous leukemia and encodes a protein with a central 118-amino-acid domain with 69% homology to the Drosophila pair-rule gene, runt. AML-1 translocation is frequently observed in acute myeloid leukemia. It is a key transactivator of tissue-specific genes of the hematopoietic and bone lineages.

Antigen
Rabbit anti-AML-1 polyclonal antibody was raised against a peptide corresponding to a sequence that is homologous in AML-1 and AML-1/ETO [amino acids 231 to 245 (AFNPQPQSQMQDTRQ) of human origin].

Genebank Info (Protein): NP_005773
Gene ID: 10189
 
AML-1/RUNX1 Antibody

Western blot analysis of AML-1 in (A) human Ramos and(B) mouse Raw cell lysate using IMG-373 at 5 ug/ml.

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Reference
1. Davis JN, McGhee L, Meyers S.  The ETO (MTG8) gene family.  Gene. 2003 Jan 16;303:1-10.


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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