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Datasheet
Polyclonal Antibody to UBE2N (ubiquitin-conjugating enzyme E2N)
Cat.No IMG-385
Description UBE2N
Format Purified
Unit 0.1 mg
Price(USD) 215.00
MSDS
Catalog No
:
IMG-385
Contents
:
100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype
:
Rabbit IgG
Purification
:
Protein G Chromatography
Species
:
Human
Host
:
Rabbit
Application
IP: please see reference (4) for details Western blot analysis: 2 ug/ml Storage Store at 4ºC, stable at 4ºC for 6 months. For long-term storage, store at -20ºC. Recommended Positive Control : human heart (Imgenex Cat. No. # 40142)
Background UBE2N (ubiquitin-conjugating enzyme E2N) is a novel human ubiquitin-conjugating enzyme with an ability to form a thiol ester linkage with ubiquitin in an ubiquitin-activating enzyme E1-dependent manner. The amino acid sequence showed 80% identity with the Drosophila's bendless gene product (ubiquitin-conjugating enzyme E2). The corresponding transcripts are highly expressed in heart, skeletal muscle, and testis. UBE2N protein may be involved in protein degradation mainly in the muscles and testis.
Antigen
This antibody was generated by immunizing rabbits with a mixture of synthetic peptides containing amino acids 2-19 and 131-148 of human UBE2N.
Reference 1. Yamaguchi T, Kim NS, Sekine S, Seino H, Osaka F, Yamao F, Kato S. J Biochem (Tokyo) 120(3): 494-497 (1996). 2. Hofmann,R.M. and Pickart,C.M. Cell 96 (5), 645-653 (1999). 3. Takada K, Hirakawa T, Yokosawa H, Okawa Y, Taguchi H, Ohkawa K. Biochem J 356(Pt 1): 199-206 (2001)
Product Citations 1. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Amanda Ewart-Toland, Paraskevi Briassouli, John P de Koning, Jian-Hua Mao, Jinwei Yuan, Florence Chan, Lucy MacCarthy-Morrogh, Bruce A J Ponder, Hiroki Nagase, John Burn, Sarah Ball, Maria Almeida, Spiros Linardopoulos, Allan Balmain. Nature Genetics 34, 403-412 (01 Aug 2003).
Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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