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Polyclonal Antibody to Cyclin E2 |
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| Catalog No: |
IMG-4019 |
| Contents: |
0.1 mg (1 mg/ml) in PBS containing 0.02% sodium azide. |
| Isotype: |
Rabbit IgG |
| Clone: |
N/A |
| Purification: |
Protein G purified |
| Species: |
Human |
| Host: |
Rabbit |
| Application: |
Western blot analysis: 1:500-1:1000 |
| Storage: |
Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles. |
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Background
Principal Names: CCNE2; G1/S-specific Cyclin E2; CYCE2; Official Gene Symbol: CCNE2 Gene ID: 9134(Human) Gene Map Locus: 8q22.1 (Human)
Cyclin E2, a 404 A.A protein, is a member of highly conserved E-type G1-cyclin family. Cyclins bind to and activate CDK kinases to form serine/threonine kinase holoenzyme complexes that regulate eukaryotic cell cycle. Cyclin E2 is localized in the nucleus and shares significant homology with Cyclin E and its expression revolves throughout the cell cycle, with peak expression during G1-S phase. Cyclin E2 binds to and acts as a regulatory subunit of CDK2. It controls the G1-S phase transition during cell cycle and regulates the activity of CIP/KIP family of CDK inhibitors. Its expression is abnormally up-regulated in certain tumors suggesting a possible therapeutic intervention. |
Antigen
ReaPeptide corresponding to amino acids 2-15 [SRRSSRLQAKQQPQC] of the Cyclin E2 protein. |
Genebank Info (Nucleotide)
NP_004693, NP_477083, NP_477097 |
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Western blot analysis of Cyclin E2 in CT10 cell line using IMG-4019 at 1:500 dilution. |
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Reference
1. Zariwala, M., Liu, J. and Xiong, Y. 1998 Oncogene 17: 2787-2798
2. JM Gudas et.al Mol Cell Biol. 19(1): 612–622 (1999 January)
3. CJ Sherr et.al GENES & DEVELOPMENT 18:2699-2711 (2004)
4. Parisi T et.al The EMBO Journal, 22 (18) 4794-4803 (2003)
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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