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Product : Antibody >> Apoptosis , Cancer Antibodies , Cell Cycle , New Antibodies , Transcription Factors >> Cyclin E2
      
 

Polyclonal Antibody to Cyclin E2

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-4019
Cyclin E2Purified
0.1 mg
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Catalog No: IMG-4019
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.1 mg (1 mg/ml) in PBS containing 0.02% sodium azide.
Isotype: Rabbit IgG
Clone: N/A
Purification: Protein G purified
Species: Human
Host: Rabbit
Application: Western blot analysis: 1:500-1:1000
Storage: Maintain at +2-8C for 3 months or at -20C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.
 

Background
Principal Names: CCNE2; G1/S-specific Cyclin E2; CYCE2; Official Gene Symbol: CCNE2 Gene ID: 9134(Human) Gene Map Locus: 8q22.1 (Human) Cyclin E2, a 404 A.A protein, is a member of highly conserved E-type G1-cyclin family. Cyclins bind to and activate CDK kinases to form serine/threonine kinase holoenzyme complexes that regulate eukaryotic cell cycle. Cyclin E2 is localized in the nucleus and shares significant homology with Cyclin E and its expression revolves throughout the cell cycle, with peak expression during G1-S phase. Cyclin E2 binds to and acts as a regulatory subunit of CDK2. It controls the G1-S phase transition during cell cycle and regulates the activity of CIP/KIP family of CDK inhibitors. Its expression is abnormally up-regulated in certain tumors suggesting a possible therapeutic intervention.

Antigen
ReaPeptide corresponding to amino acids 2-15 [SRRSSRLQAKQQPQC] of the Cyclin E2 protein.

Genebank Info (Nucleotide): NP_004693, NP_477083, NP_477097

 
Cyclin E2 Antibody

Western blot analysis of Cyclin E2 in CT10 cell line using IMG-4019 at 1:500 dilution.

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Reference
1. Zariwala, M., Liu, J. and Xiong, Y. 1998 Oncogene 17: 2787-2798
2.  JM Gudas et.al Mol Cell Biol. 19(1): 612622 (1999 January)
3. CJ Sherr et.al GENES & DEVELOPMENT 18:2699-2711 (2004)
4. Parisi T et.al The EMBO Journal, 22 (18) 4794-4803 (2003)


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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