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Product : Antibody >> Apoptosis , Cancer Antibodies , Cell Cycle , New Antibodies , Toll-like Receptor Associ.. >> ACT
      
 

Polyclonal Antibody to ACT

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-4043
ACTPurified
0.1 mg
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Catalog No: IMG-4043
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions – novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.1 mg (1 mg/ml) in PBS containing 0.02% sodium azide.
Isotype: Rabbit IgG
Clone: N/A
Purification: Protein G purified
Species: Human
Host: Rabbit
Application: Western blot analysis: 1:500-1:1000
Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.
 

Background
Principal Names: Activator of CREM in Testis; (FHL5) Four and half LIM domains 5; 1700027G07Rik; dJ393D12.2, FLJ33049 Official Gene Symbol: FHL5 Gene ID: 9457 (Human) Gene Map Locus: 6p16.1-1p16.3 (Human) FHL proteins are tissue specific cofactors of CREB and CREM and participate in regulation of various physiological processes. These proteins are characterized by the presence of 4 LIM domains and a LIM-half domain at the N-terminus. ACT, a 33KDa protein, is a novel member of this family. It is specifically expressed in male testis and consists of a central activation domain. It is coordinately expressed with CREM and plays a vital role in spermatogenesis. It binds specifically to CREM and powerfully stimulates its transcriptional activation, essential for differentiation of spermatids into mature spermatozoa. It activates CREM in a phosphorylation- and CBP-independent manner. Protein-protein interactions with a Kinesin KIF17B regulate ACT activity in mouse.

Antigen
Peptide corresponding to the N terminus of ACT.

 
ACT Antibody

Western blot analysis of ACT in testis extract using IMG-4043 at 1:500 dilution.

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Reference
1. Fimia, G. M. et. al. Nature (1999) 398: 165-169
2. Fimia GM et.al Mol Cell Endocrinol. 179(1-2):17-23 (2001 Jun 20)
3. Macho B et.al Science 298(5602):2388-90 (2002 Dec 20)


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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