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Product : Antibody >> Apoptosis , Cancer Antibodies , CD Markers , Cell Cycle , New Antibodies >> CD72
      
 

Polyclonal Antibody to CD72

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-4077
CD72Purified
0.1 mg
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Catalog No: IMG-4077
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.1 mg (1 mg/ml) in PBS containing 0.02% sodium azide.
Isotype: Rabbit IgG
Clone: N/A
Purification: Protein G purified
Species: Human
Host: Rabbit
Application: Western blot analysis: 1:500-1:1000
Storage: Maintain at +2-8C for 3 months or at -20C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.
 

Background
Principal Names: CD72; B-cell differentiation antigen CD72; Lyb-2; Official Gene Symbol: CD72 Gene ID: 971 (Human) Gene Map Locus: 19p13.3 (Human) CD72, a human homolog of murine Lyb-2, is a 45KDa B-cell transmembrane glycoprotein. It is expressed in all stages of B-cell development except plasma cells and functions as a vital B-cell co-receptor. It exhibits a dual role during B-cell activation and development. It mediates positive signaling through activation of Grb2-Sos-Ras pathway resulting in activation of several downstream pathways including ERK and JNK pathways. ITIM motif present in the cytoplasmic domain of CD72 recruits SHP-1 upon tyrosine phosphorylation, resulting in negative regulation of BCR signaling. CD72 functions as a novel receptor for CD100/Sema4D, resulting in dephosphorylation of CD72 and regulation of negative signaling by CD72.

Antigen
Peptide corresponding to amino acids 305-317 [KDWKLTDDTQRTRI] of the 42 kDa human CD72 protein.

Genebank Info (Protein): NP_001773
Gene ID: 971

Genebank Info (Nucleotide): NP_001773

 
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Reference
1. Von Hoegen et al. (1990). J Immunol 144(12):4870-7
2. Adachi et.al J Immunol., 160(10):4662-5 (1998 May 15)
3. Wu HJ et.al J Immunol., 167(3):1263-73 (2001 Aug 1)
4. Kumanogoh et.al Immunity 13(5):621-31 (2000 Nov)


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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