Product : Antibody >> Apoptosis , Cancer Antibodies , Cell Cycle , New Antibodies , Transcription Factors >> CDC4 (69 kDa isoform)

Polyclonal Antibody to Cdc4 (69 kDa isoform)

Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
CDC4 (69 kDa isoform)Purified
0.1 mg
Catalog No: IMG-4118
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Contents: 0.1 mg (1 mg/ml) in PBS containing 0.02% sodium azide.
Isotype: Rabbit IgG
Clone: N/A
Purification: Protein G purified
Species: Human
Host: Rabbit
Application: Western blot analysis: 1:500-1:1000
Storage: Maintain at +2-8C for 3 months or at -20C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of malignancies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.

A synthethic peptide corresponding to amino acids 1-11 (MCVPRSGLILS) of human Cdc4 was used as immunogen, GenBank no. NP_060785.2.

Application Notes
The antibody recognizes the N terminus of the 69 kDa isoform of human Cdc4.

Genebank Info (Protein): NP_001013433
Gene ID: 55294

1. Strohmaier H. et al. Nature 2001 Sep 20;413(6853):316-22

Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.






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