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Product : Antibody >> Apoptosis , Cancer Antibodies , Cell Cycle , New Antibodies , Transcription Factors >> DEDD2/Flame-3
      
 

Polyclonal Antibody to DEDD2

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-4138
DEDD2/Flame-3Purified
0.1 mg
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Catalog No: IMG-4138
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.1 mg (1 mg/ml) in PBS containing 0.02% sodium azide.
Isotype: Rabbit IgG
Clone: N/A
Purification: Protein G purified
Species: Human, Mouse
Host: Rabbit
Application:
Storage: Maintain at +2-8C for 3 months or at -20C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.
 

Background
A novel Death Effector Domain-containing protein, DEDD2, is closest in amino acid sequence homology to Death Effector Domain-containing DNA-binding protein, DEDD. DEDD2 is expressed widely in adult human tissues with highest levels in liver, kidney and peripheral blood leukocytes. DEDD2 interacts with FLIP, but not with FADD or Caspase 8. Over-expression of DEDD2 induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas(CD95/APO-1), TRAIL(Apo2L), or FADD. These findings suggest that DEDD2 is involved in the regulation of nuclear events mediated by the extrinsic apoptosis pathway.

Antigen
Peptide corresponding to amino acids 144-129 of DEDD2.

Genebank Info (Protein): NP_579874
Gene ID: 162989
SwissProt: Q8WXF8
 
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Reference
1. Roth, W. et al. J. Biol. Chem. (2002) In press


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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