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Polyclonal Antibody to CLAC-P (NC2-1 region) |
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| Catalog No: |
IMG-4153 |
| Contents: |
0.1 mg (1 mg/ml) in PBS containing 0.02% sodium azide. |
| Isotype: |
Rabbit IgG |
| Clone: |
N/A |
| Purification: |
Protein G purified |
| Species: |
Mouse, Human |
| Host: |
Rabbit |
| Application: |
Western blot analysis: 1:500 |
| Storage: |
Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles. |
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Background
Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100 kDa polypeptides in Alzheimer's disease (AD) brains. The 9D2 antigen was identified as CLAC (collagen-like Alzheimer amyloid plaque component), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD. |
Antigen
Peptide corresponding to amino acids 171-183 [NHGFLSADQQLIK] of the NC2-1 region of human and mouse CLAC-P. |
Application Notes
Detects bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cerebral amyloid angiopathy. |
Genebank Info (Protein)
NP_942014 |
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Western blot analysis of CLAC-P, using Img-4153 and IMG-4154 at 1:500 dilution on 100 ug of formic acid extracts of Alzheimer diseased brain. |
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Reference
1. Hashimoto,T. et. al. EMBO J. 21 (7), 1524-1534 (2002).
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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