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Product : Antibody >> Apoptosis , Cancer Antibodies , Cell Cycle , New Antibodies , Transcription Factors >> CIDE-3
      
 

Polyclonal Antibody to CIDE-3

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-4158
CIDE-3Purified
0.1 mg
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Catalog No: IMG-4158
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.1 mg (1 mg/ml) in PBS containing 0.02% sodium azide.
Isotype: Rabbit IgG
Clone: N/A
Purification: Protein G purified
Species: Human
Predicted React: Mouse
Host: Rabbit
Application: Western blot analysis: 1:500-1:1000
Storage: Maintain at +2-8C for 3 months or at -20C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.
 

Background
DNA fragmentation is one of the critical steps in apoptosis, which is induced by DNA fragmentation factor (DFF). DFF is composed of two subunits, a 40 kDa caspase-activated nuclease (DFF40) and a 45 kDa inhibitor (DFF45). Recently a novel family of cell-death-inducing DFF45-like effectors (CIDEs) has been identified. Human CIDE-3 is a novel member of CIDEs. There are 2 transcripts, CIDE-3 and CIDE-3alpha, were present in HepG2 and A375 cells. Consistent with its chromosome localization at 3p25, a region associated with high frequency loss of heterozygosity in many tumours, CIDE-3 may play an important role in prevention of tumorigenesis.

Antigen
Peptide corresponding to amino acids 10-25 [LLYPKSLSRHVSVRTS] of the 27 kDa human CIDE-3 protein.

Application Notes
The mouse sequence is 93% positive, 80% identical to hCIDE-3, so this antibody may react with the mouse homolog FSP27. 

Genebank Info (Protein): NP_071377
Gene ID: 63924
SwissProt: Q96AQ7
 
CIDE-3 Antibody

Western blot analysis of CIDE-3 using IMG-4158 at 1:1000 dilution on 30ug HepG2 cell lysate.

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Reference
1. Liang, L. et al. Biochem. J. 370 (Pt 1), 195-203 (2003)


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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