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Datasheet
Polyclonal Antibody to Ku80/XRCC5
Cat.No IMG-4174
Description Ku80/XRCC5
Format Purified
Unit 0.1 mg
Price(USD) 225.00
MSDS
Catalog No
:
IMG-4174
Contents
:
0.1 mg (1 mg/ml) in PBS containing 0.02% sodium azide.
Isotype
:
Rabbit IgG
Clone
:
N/A
Purification
:
Protein G purified
Species
:
Hamster, Human, Mouse, Rat
Host
:
Rabbit
Application
Western blot analysis: 1:500-1:1000 Storage Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.
Background Telomere length maintenance, an activity essential for chromosome stability and genome integrity, is regulated by telomerase- and telomere-associated factors. The DNA repair protein Ku (a heterodimer of Ku70 and Ku80 subunits) associates with mammalian telomeres and contributes to telomere maintenance. The Ku heterodimer functions at two kinds of DNA ends: telomeres and double-strand breaks. The role that Ku plays at these two classes of termini must be distinct, because Ku is required for accurate and efficient joining of double-strand breaks while similar DNA repair events are normally prohibited at chromosome ends.
Antigen
Peptide corresponding to amino acids 323-338 [FSKVDEEQMKYKSEGK] of the 80 kDa Ku80 protein.
Application Notes
Sequence is 100% conserved between human, mouse rat and hamster.
Reference 1. Park S. J. et al. J Biol Chem. 2004 Feb 13;279(7):6046-55
Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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The protocols described here can be used as a guideline for use of IMGENEX Histo-array slides. Modifications may be necessary depending on the target gene(s), antibodies, or nucleic acid probes.
The protocols described here can be used as a guideline for use of IMGENEX Histo-array slides. Modifications may be necessary depending on the target gene(s), antibodies, or nucleic acid probes.
