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Polyclonal Antibody to AKT2/3 |
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| Catalog No: |
IMG-421 |
| Contents: |
100 ug in 200 ul PBS containing 0.02% sodium azide. Sodium azide is highly toxic. |
| Isotype: |
Rabbit IgG |
| Clone: |
N/A |
| Purification: |
Protein G Chromatography |
| Species: |
Human |
| Host: |
Rabbit |
| Application: |
Western blot analysis: 1-2 ug/ml |
| Storage: |
Store at 4°C for six months. For long term storage, store at -20°C. |
Recommended
Positive Control: |
HeLa |
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Background
AKT, protein kinase B (PKB), is a serine/threonine kinase, which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). AKT2 is amplified and overexpressed in some human cancers. |
Antigen
Amino acids 319-331 of human AKT2. This sequence is 100% homologous in AKT3. |
Genebank Info (Protein)
NP_001617 |
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Western blot analysis of AKT2/3 using IMG-421 at 1 µg/ml against 15 µg of HeLa lysate. |
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Reference
1. Alessi D.R., et al. EMBO J. 15: 6541-6551 (1996).
2. Ferring P., et al. Oncogene 18: 6129-6134 (1999).
3. Kandel E.S., et al.. Exp. Cell Res. 253: 210-219 (1999).
4. Cantley, L.C., et al. Proc Natl Acad Sci, USA, 96: 420-4245 (1999)
5. Cheng J.Q PNAS 89: 9267-9271 (1992)
6. Cheng J.Q PNAS 93: 3636-3641 (1996)
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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