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Polyclonal Antibody to ABIN-2 |
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| Catalog No: |
IMG-434 |
| Contents: |
100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Isotype: |
Rabbit IgG |
| Purification: |
Protein G Chromatography |
| Species: |
Human, Mouse, Rat |
| Host: |
Rabbit |
| Application: |
Western blot analysis: 2-4 ug/ml |
| Storage: |
Store at 4°C for six months. For long term storage, store at -20°C. |
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Background
ABIN-2, TNFAIP3 interacting protein 2, binds to the COOH-terminal zinc finger domain of A20. NF-kB activation induced by TNF and interleukin-1 is inhibited by overexpression of ABIN-2. The latter also inhibits NF-kB activation induced by overexpression of receptor-interacting protein or TNF receptor-associated factor 2. A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB)Activation (ABIN-2) binds to A-20. ABIN-2 interferes with NF-kB activation upstream of the IKK complex and might contribute to NF-kB inhibitory function of A-20. |
Antigen
This antibody was generated by immunizing rabbits with synthetic peptides of human ABIN-2. It cross-reacts with mouse ABIN-2. |
Genebank Info (Protein)
NP_077285 |
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Western blot analysis of ABIN-2 in A) human brain, B) mouse brain and C) rat brain lysate using IMG-434 at 3 ug/ml. |
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Reference
1. S. Van Huffel, et al. JBC 276(32): 30216-30223 (2001)
2. Klinkenberg M, et al. FEBS Letter 498(1):93-97(2001)
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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