Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA by spontaneous hydrolysis, DNA damaging agents or DNA glycosylases that remove specific abnormal bases. ClassII AP endonucleases act to repair this damage by cleaving the phosphodiester backbone. It is primarily located in the nucleus but is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). |
Antigen
This antibody was generated by immunizing rabbits with EELRALDSEGRALLTQHKI (aa122-140) and GQAKTSEAKDEKELRTSF (aa438-455) peptides of human APEXL2. Genbank accession no. NM_014481 |
Application Notes
In HeLa, a 54 kDa band is observed. |
| Genebank Info (Protein): NP_055296 |
| Gene ID: 27301 |
Genebank Info (Nucleotide): NM_014481 |
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Western blot analysis of APEXL2 in HeLa cell lysates using IMG-466 at a dilution of 1:500. |
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Reference
1. Hadi, M..Z., et al., Homo sapiens APE2 protein (APE2) mRNA. Unpublished
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