Product : Antibody >> DNA Methylation & Rep.. >> CGBP

Polyclonal Antibody to CGBP (CpG binding protein)

Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
0.2 mL
Catalog No: IMG-477
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Contents: 100 ug antibody in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit Ig
Clone: N/A
Purification: Protein G Chromatography
Species: Human
Host: Rabbit
Application: Western blot analysis: 1:1000
Storage: Store at 4C, stable at 4C for 6 months. For long-term storage, store at -20C.
Positive Control:
human spleen

Human CpG binding protein (hCGBP) contains three cysteine-rich domains, two of which exhibit homology to the plant homeodomain finger domain and the third cysteine-rich domain conforms to the CXXC motif identified in DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. A fragment of hCGBP that contains the CXXC domain binds to an oligonucleotide probe containing a single CpG site, and this complex is disrupted by distinct oligonucleotide competitors that also contain a CpG motif(s). CBGP plays an important part in embryonic viability and peri-implantation development. Native hCGBP is detected as an 88-kDa protein by Western analysis and is ubiquitously expressed. CGBP trans-activates promoters that contain CpG motifs but not promoters in which the CpG is ablated suggesting that hCGBP is a transcriptional activator that recognizes unmethylated CpG dinucleotides.

This polyclonal antibody was raised against a mixture of synthetic peptides containing 73-90 and 641-656 amino acids residues of human CGBP.

Genebank Info (Protein): NP_001095124
Gene ID: 30827
SwissProt: Q9P0U4
CGBP Antibody

Western blot analysis of CGBP using IMG-477 at 1:1,000 dilution against 15 ug/lane of human spleen lysate. Immunoreactivity was determined using SuperSignal system (Pierce) and by exposing to the film for 15 minutes.


1. Voo KS, Carlone DL, Jacobsen BM, Flodin A, and Skalnik DG. Mol Cell Biol, 20 (6): 2108-2121 (2000).
2. Carlone DL, Skalnik DG. Mol Cell Biol 21(22):7601-7606 (2001).
3. Lee JH, Skalnik DG. J Biol Chem 2002 Aug 27; [epub ahead of print]

Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.






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