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Product : Antibody >> TNF Family & Death Re.. >> DR3
      
 

Polyclonal Antibody to DR3

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-5024
DR3Purified
0.1 mg
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Catalog No: IMG-5024
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 ug antibody in 200 ul PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit IgG
Purification: Protein G Chromatography
Species: Human
Host: Rabbit
Application: Western blot analysis: 0.5-2 ug/ml
Storage: Store DR3 antibody at 4oC, stable for 6 months. For long-term storage, store antibody at -20oC.
Recommended
Positive Control:
HeLa
 

Background
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3 (Wsl-1, Apo-3, TRAMP, LARD1-5). The ligand for this novel cell death receptor has not yet been defined. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kB activation.

Antigen
The antibody was developed by immunizing rabbits with a synthetic peptide corresponding to amino acids 398-417 of human DR3 protein.

Genebank Info (Protein): NP_042997
 
DR3 Antibody

Western blot analysis of DR3 using DR3 polyclonal antibody. HeLa cell lysate probed using DR3 antibody 0.5 ug/ml.

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Reference
1. Chinnaiyan AM; O'Rourke K; Yu GL; Lyons RH; Garg M; Duan DR; Xing L; Gentz R; Ni J; Dixit VM. Science, 1996;274:990-2.
2. Kitson J; Raven T; Jiang YP; Goeddel DV; Giles KM; Pun KT; Grinham CJ; Brown R; Farrow SN. Nature, 1996;384:372-5.
3. Marsters SA; Sheridan JP; Donahue CJ; Pitti RM; Gray CL; Goddard AD; Bauer KD; Ashkenazi A. Curr Biol, 1996;6:1669-76.
4. Bodmer JL; Burns K; Schneider P; Hofmann K; Steiner V; Thome M; Bornand T; Hahne M; Schroter M; Becker K; et al. Immunity, 1997;6:79-88.
5. Screaton GR; Xu XN; Olsen AL; Cowper AE; Tan R; McMichael AJ; Bell JI. Proc. Nat. Acad. Sci. USA. 1997;94:4615-9.


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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