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Product : Antibody >> New Antibodies , NF-kB Pathway , TNF Family & Death Re.. >> RANK (CD265, TNF11aR, ODFR)
      
 

Polyclonal Antibody to RANK/TNF11aR/ODFR

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-5116A
RANK (CD265, TNF11aR, ODFR) Purified
0.1 mg
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Catalog No: IMG-5116A
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions – novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype: Rabbit IgG
Clone: N/A
Purification: Protein G chromatography
Species: Human, Mouse
Host: Rabbit
Application: Western blot analysis: 1-3 ug/ml
Storage: Store at 4°C, stable for 6 months. For long-term storage, store at -20°C.
Recommended
Positive Control:
RAW cell lysate
 

Background
Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand  (RANKL/TRANCE/ OPGL) (mAbs to RANKL is also available from Imgenex, Cat # IMG-133) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathway. Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2.

Antigen
A synthetic peptide corresponding to amino acid residues 603-613 of human RANK. Genbank accession number: NP_003830.               

Genebank Info (Protein): NP_003830
Gene ID: 8792
 
RANK (CD265, TNF11aR, ODFR) Antibody

Western blot analysis of RANK in RAW cell lysate.

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Reference
1. Anderson,D.M., Maraskovsky,E., Billingsley,W.L., Dougall,W.C., et al. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390 (6656), 175-179 (1997).
2. Darnay,B.G., Ni,J., Moore,P.A. and Aggarwal,B.B. Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J. Biol. Chem. 274 (12), 7724-7731 (1999).
3. Hsu,H., Lacey,D.L., Dunstan,C.R., Solovyev,I., Colombero,A., et al. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc. Natl. Acad. Sci. U.S.A. 96 (7), 3540-3545 (1999).
4. Dougall,W.C., Glaccum,M., Charrier,K., Rohrbach,K., Brasel,K., De Smedt,T.,  et al. RANK is essential for osteoclast and lymph node development. Genes Dev. 13 (18), 2412-2424 (1999).
5. Karsdal,M.A., Hjorth,P., Henriksen,K., Kirkegaard,T., Nielsen,K.L., et al. Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression. J. Biol. Chem. 278 (45), 44975-44987 (2003).


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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