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Datasheet
Polyclonal Antibody to Anterior Gradient 2 (AGR2) Homolog
Cat.No IMG-5279A
Description Anterior Gradient 2 Homolog (AGR2)
Unit 0.1 mg
Price(USD) 215.00
MSDS
Catalog No
:
IMG-5279A
Contents
:
100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype
:
Rabbit IgG
Clone
:
N/A
Purification
:
Protein G Chromatography
Species
:
Human
Predicted React
:
Bovine, Chicken, Chimpanzee, Dog, Mouse, Orangutan, Rat, Xenopus
Host
:
Rabbit
Application
ELISA: 1:100-1:1000 IHC (paraffin): 1:100 Storage Store at 4 deg C, stable for 6 months. For long-term storage, store at -20 deg C.
Background
hAG-2 and hAG-3 are recently discovered human homologues of the secreted Xenopus laevis proteins XAG-1/2 (AGR-1/2) that are expressed in the cement gland, an ectodermal organ in the head associated with anteroposterior fate determination during early development(1). Although the roles of hAG-2 and hAG-3 in mammalian cells are unknown, both proteins share a high degree of protein sequence homology and lie adjacent to one another on chromosome 7p21.
Antigen
This antibody was developed against synthetic peptides corresponding to amino acids 55-72 (TQTYEEALYKSKTSNKPL) of human AGR2; Genbank accession no. NP_006399.1
Application Notes
Researchers are encouraged to use the sequence and accession number (NP_006399.1) that were used to design the peptide immunogen in order to assess potential cross-reactivity of the antibody to their species of interest.
Immunohistochemical staining with IMG-5279A, anti-AGR2 antibody, in formalin-fixed, paraffin-embedded normal colon tissue at 1:100 dilution.
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Related Products
Reference 1. Fletcher GC et al.,Br J Cancer. 2003 Feb 24;88(4):579-85. 2. Petek E et al.,Cytogenet Cell Genet. 2000;89(3-4):141-2.
Product Citations 1. Proteomic changes during intestinal cell maturation in vivo. Chang J, MR Chance, C Nicholas, N Ahmed, S Guilmeau, M Flandez, D Wang, D-S Byun, S Nasser, JM Albanese, GA Corner, BG Heerdt, AJ Wilson, LH Augenlicht, JM Mariadason. J Proteomics 71:530-546 (2008). IHC (paraffin): mouse intestine tissue, Fig 5. 2. The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation. Wang Z, Y Hao, A Lowe. Cancer Research 68: 492-497 (2008). IHC (paraffin): mouse intestine tissue, Fig 3C. 3. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. Chen G, TR Korfhagen, Y Xu, J Kitzmiller, SE Wert, Y Maeda, A Gregorieff, H Clevers, JA Whitsett. J Ciin Invest 119:2914-2924 (2009). IHC (paraffin): transgenic mouse lung tissue, Fig 4B, C.
Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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IMG-5279A [Polyclonal Antibody to Anterior Gradient 2 (AGR2) Homolog]