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Datasheet
Polyclonal Antibody to Aldo-keto reductase family 1 member B10 (AKR1B10)
Cat.No IMG-5285A
Description Aldo-keto reductase family 1 member B10 (AKR1B10)
Unit 0.1 mg
Price(USD) 205.00
MSDS
Catalog No
:
IMG-5285A
Contents
:
100 ug in 200 ul PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype
:
Rabbit IgG
Clone
:
NA
Purification
:
Protein G Chromatography
Species
:
Human, Mouse, Rat
Predicted React
:
Chimpanzee
Host
:
Rabbit
Application
Western blot analysis: 1-3 ug/ml Storage Store at 4°C, stable for 6 months. For long-term storage, aliquot and store at -20°C. Recommended Positive Control : human, mouse or rat liver tissue lysate
Background
Principal Names: Aldose reductase like(ARL); Human small intestine reductase(HIS reductase); AKR1B11; AKR1B12; MGC14103 Aldo-Keto reductase family 1, member 10 (AKR1B10); Official Gene Symbol- AKR1B10 Gene ID- 57016(Human) Gene Map Locus- 7q33(Human)
ARK1B10, a 316A.A protein, catalyzes efficient reduction of aliphatic and aromatic aldehydes. It the first cytosolic NADP (H)-dependent retinal reductase described in humans and is characterized by the presence of a novel NADP binding motif. Due to its ability to convert glucose to sorbitol, AKR1B10 may have a role in development of secondary diabetic complications. It is abundantly expressed in adrenal gland, small intestine and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle and its levels are up regulated in certain cancers such as hepatocellular carcinoma.
Antigen
A portion of amino acids 100-200 of human AKR1B10 protein were used as the immunogen.
Application Notes
The NCBI accession number for AKR1B10 is EAL24068.
Western blot analysis of AKR1B10 in A) human, B) mouse, and C) rat liver tissue lysate using IMG-5285A at 1 ug/ml.
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Reference 1. Scherer,S.W., et al. Human chromosome 7: DNA sequence and biology. Science 300 (5620), 767-772 (2003). 2. Cao, D et.al J. Biol. Chem. 273: 11429-11435 (1998) 3. Scuric, Z et.al Hepatology 27, 943–950 (1998) 4. Bernat CROSAS et.al Biochem. J. 373; 973–979 (2003)
Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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IMG-5285A [Polyclonal Antibody to Aldo-keto reductase family 1 member B10 (AKR1B10) ]
