Product : Antibody >> DNA Methylation & Rep.. >> AID/AICDA

Peptide-affinity Purified Polyclonal Antibody to AID/AICDA

Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
AID/AICDAPurified, Peptide Affinity
0.1 mg
Catalog No: IMG-5410-2
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Contents: 0.1 mg of purified antibody in PBS containing 0.02% sodium azide.
Isotype: Rabbit Ig
Clone: N/A
Purification: Antigen Affinity Chromatography
Species: Human, Mouse
Host: Rabbit
Application: IF/ICC: 10 ug/ml
Western blot analysis: 1-2 ug/ml
Storage: Store at 4C.
Positive Control:
Whole cell lysate from Ramos cells can be used as positive control.

Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. It is necessary for somatic hypermutation and class switch recombination in B cells, but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms. Although it is structurally and functionally similar to the APOBEC proteins, it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G.

A synthetic peptide corresponding to 14 amino acids near the carboxy-terminus of human AID was used as immunogen.

Genebank Info (Protein): NP_065712
Gene ID: 57379
AID/AICDA Antibody

Western blot analysis of AID in Ramos whole cell lysate with anti-AID using IMG-5410 at 2 g/ml in either the (A) absence or (B) presence of blocking peptide.

AID/AICDA Antibody IMG-5410-2

Immunocytochemistry analysis of AID in Ramos cells using IMG-5410 at 10 ug/ml.


1. Muramatsu M, Sankaranand VS, Anant S, et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J. Biol. Chem. 1999; 274:18470-6.
2. Muramatsu M, Kinoshita K, Fagarasan S, et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000; 102:553-63.
3. Greeve J, Philipsen A, Krause K, et al. Expression of activation-induced cytidine deaminase in human B-cell Hodgkin lymphomas. Blood 2003; 101:3574-80.
4. Cascalho M. Advantages and disadvantages of cytidine deamination. J. Immunol. 2004; 172:6513-8.
5. Sheehy AM, Gaddis NC, Choi JD, et al. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 2002; 418:646-50.

Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.






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