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Datasheet
Peptide-affinity Purified Polyclonal Antibody to IRAK-2 (C2)
Cat.No IMG-5495-2
Description IRAK-2 (C2)
Format Purified, Peptide Affinity
Unit 0.1 mg
Price(USD) 355.00
MSDS
Catalog No
:
IMG-5495-2
Contents
:
0.1 mg of purified antibody in PBS containing 0.02% sodium azide.
Isotype
:
Rabbit Ig
Clone
:
N/A
Purification
:
Antigen Affinity Chromatography
Species
:
Mouse
Host
:
Rabbit
Application
Western blot analysis: 0.5-1 ug/ml Storage Store at 4°C. Recommended Positive Control : Whole cell lysate from A-20 cells can be used as positive control.
Background The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-?B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family has been identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-?B activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-?B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. Unlike human IRAK2, murine IRAK2 exists as four alternately spliced isoforms (IRAK2a-d), with two isoforms (IRAK2c and d) acting in an inhibitory fashion. IRAK2 is expressed in a variety of tissues.
Western blot analysis of IRAK2 in A-20 whole cell lysate using IMG-5495 at (A) 0.5, (B) 1, and (C) 2 µg/ml.
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Reference 1. Muzio M, Ni J, Feng P, et al. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997; 278:1612-5. 2. Zhang FX, Kirschning CJ, Mancinelli R, et al. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J. Biol. Chem. 1999; 274:7611-4. 3. Yang RB, Mark MR, Gurney AL, et al. Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. J. Immunol. 1999; 163:639-43. 4. Hardy MP and O’Neill LAJ. The murine IRAK2 gene encodes four alternately spliced isoforms, two of which are inhibitory. J. Biol. Chem. 2004; 279:27699-708.
Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
Related Products
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IMG-5495-2 [Peptide-affinity Purified Polyclonal Antibody to IRAK-2 (C2)]
