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Product : Antibody >> TNF Family & Death Re.. >> DR6
      
 

Polyclonal Antibody to DR6

 
Cat. No.DescriptionFormatUnitPrice(USD)QuantityBulk Quotation
IMG-5604-2
DR6Purified
0.1 mg
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Catalog No: IMG-5604-2
Imgenex is now a part of Novus Biologicals! All orders, billing and shipments will be received from Novus. Please contact Novus directly for any questions novus@novusbio.com. To insure proper processing of you order, please insure that your purchase orders show Novus Biologicals as the vendor.
Contents: 0.1 mg of purified antibody in PBS containing 0.02% sodium azide.
Isotype: Rabbit Ig
Clone: N/A
Purification: DEAE-column chromatography
Species: Human
Host: Rabbit
Application: Western blot analysis: 1:500-1:2000
Storage: Store at 4C.
Recommended
Positive Control:
K562 or Raji whole cell lysate.
 

Background
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.

Antigen
Human DR6 (NT) peptide.

Genebank Info (Protein): NP_043000
Gene ID: 1487974
 
DR6 Antibody

Western blot analysis of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide using IMG-5604 at 1:500 dilution.

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Reference
1. Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett 1998;431:351-6


Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.


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