Datasheet

Polyclonal Antibody to TIRAP/Mal (CT) Cat.No IMG-5647-2 Description TIRAP/Mal (CT) Format Purified Unit 0.1 mg Price(USD) 355.00 MSDS Catalog No : IMG-5647-2 Contents : 0.1 mg of purified antibody in PBS containing 0.02% sodium azide. Isotype : Rabbit Ig Clone : N/A Species : Human, Mouse, Rat Host : Rabbit Application IHC (paraffin): 2 ug/ml Western blot analysis: 0.5-2 ug/ml Storage Store at 4°C. Recommended Positive Control : Human heart cell lysates. Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-?B and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling. Antigen Murine TIRAP (CT) peptide. Genebank Info (Protein) NP_001034750   Western blot analysis of TIRAP in human heart cell lysates using IMG-5647 at (A) 0.5, (B) 1, and (C) 2 µg/ml. IHC analysis of human heart cells using IMG-5647 at 2 µg/ml. ffsdf Related Products 1. IMG-2006-1 [TIRAP Inhibitory Peptide Set Functions as a TIRAP decoy by binding to TIR interacting domains on specific TLR receptors.] 2. IMG-2006-5 [TIRAP Inhibitory Peptide Set Functions as a TIRAP decoy by binding to TIR interacting domains on specific TLR receptors.] Reference 1. Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77. 2. Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.    3. Janeway CA Jr and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216. 4. O’Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9. 5. McGettrick AF and O’Neill LAJ. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Imm. 2004; 41:577-82. 6. Yamamoto Y, Sato S, Hemmi H, et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 2002; 420:324-9.    7. Hoorng T, Barton GM, FlavellRA, et al. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 2002; 420:329-333.    Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.

Related Products

Related Product(s) of the Catalog # IMG-5647-2

Cat. No Description Species Qty Price(USD) IMG-2006-1 TIRAP Inhibitory Peptide Set Functions as a TIRAP decoy by binding to TIR interacting domains on specific TLR receptors. 2 mg 360.00 IMG-2006-5 TIRAP Inhibitory Peptide Set Functions as a TIRAP decoy by binding to TIR interacting domains on specific TLR receptors. 5 mg 805.00

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IMG-5647-2 [Polyclonal Antibody to TIRAP/Mal (CT)]

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