Datasheet

Polyclonal Antibody to TLR2/CD282 Cat.No IMG-5651-2 Description TLR2/CD282 Unit 0.1 mg Price(USD) 365.00 MSDS Catalog No : IMG-5651-2 Contents : 0.1 mg of purified antibody in PBS containing 0.02% sodium azide. Isotype : Rabbit Ig Clone : N/A Species : Human, Mouse Host : Rabbit Application IHC (paraffin): 2 ug/ml Western blot analysis: 0.5-2 ug/ml Storage Store at 4°C. Recommended Positive Control : A20 cell lysates Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-?B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer can recognize a variety of bacterial and mycoplasma lipoproteins respectively. Antigen Human TLR2 (NT) peptide. Genebank Info (Protein) NP_003255   Western blot analysis of TLR2 in A20 cell lysates using IMG-5651 at 1 ug/ml in the presence (A) and absence (B) of its blocking peptide. Immunohistochemical analysis of TLR2 in human spleen cells using IMG-5651 at 2 ug/ml ffsdf Related Products 1. IMG-2201 [Pam3CSK4, TLR1 and TLR2 Ligand] 2. IMG-2206 [MALP-2, TLR6/TLR2 ligand] Reference 1. Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77. 2. Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76. 3. Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216. 4. O’Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9. 5. McGettrick AF and O’Neill LAJ. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Imm. 2004; 41:577-82. 6. Asehnoune K, Strassheim D, Mitra S, et al. Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB. Cell Signal. 2005; 17:385-94. 7. Wetzler LM. The role of Toll-like receptor 2 in microbial disease and immunity. Vaccine 2003; 21 Suppl 2:55-60. Research purposes only. Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.

Related Products

Related Product(s) of the Catalog # IMG-5651-2

Cat. No Description Species Qty Price(USD) IMG-2201 Pam3CSK4, TLR1 and TLR2 Ligand 0.025 mg 60.00 IMG-2206 MALP-2, TLR6/TLR2 ligand 2.0 µg 65.00

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IMG-5651-2 [Polyclonal Antibody to TLR2/CD282]

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