Background
Principal Names: Formyl Peptide receptor 1 (FPR1); fMet-Leu-Phe receptor (fMLP receptor); N-formylpeptide chemoattractant receptor; FMLP; Official Gene Symbol: FPR1 Gen Bank Accession Number: NP_002020 Gene ID: 2357 (Human) Gene Map Locus: 19q13.4 (Human)
FPR1 is a member of chemoattractant/chemokine GPCRs expressed mainly on leukocytes, neutrophils and monocytes. FPR1 is a seven transmembrane pertussis toxin-sensitive GPCR and binds to formylated peptides generated by bacteria resulting in leukocyte trafficking to the site of inflammation. Ligand binding to FPR results in activation of multiple effectors including phospholipase C leading to calcium mobilization and PKC activation. Other implications of FPR signaling include polarization of actin cytoskeletion, activation of various integrins, increased cell migration, phagocytosis, degranulation and release of reactive oxygen intermediates. |
Reference
1. Gripentrog,J.M. and Miettinen,H.M. Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on beta-arrestin translocation or receptor endocytosis. Cell. Signal. 17 (10), 1300-1311 (2005)
2. Paruch,S., El-Benna,J., Djerdjouri,B., Marullo,S. and Perianin,A. A role of p44/42 mitogen-activated protein kinases in formyl-peptide receptor-mediated phospholipase D activity and oxidant production. FASEB J. 20 (1), 142-144 (2006)
3. Zhou,Y., Bian,X., Le,Y., Gong,W., Hu,J., Zhang,X., Wang,L., Iribarren,P., Salcedo,R., Howard,O.M., Farrar,W. and Wang,J.M. Formylpeptide receptor FPR and the rapid growth of malignant human gliomas. J. Natl. Cancer Inst. 97 (11), 823-835 (2005)
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