Polyclonal Antibody to SODD

Background
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains (1). SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines

Antigen
Rabbit polyclonal SODD antibody was raised against a peptide corresponding to amino acids near the amino terminus of human SODD.

Application Notes
SODD antibody can be used for detection of SODD by Western blot at 0.5 to 1 ug/ml. (Optimal dilution should be determined by user.) HeLa and THP-1 whole cell lysate can be used as positive control and an approximately 60 kDa band can be detected. SODD antibody is human, mouse, and rat reactive.

Genebank Info (Protein)
NP_004865

Reference