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Datasheet
Peptide-affinity Purified Polyclonal Antibody to G Protein-Coupled Receptor 83 (GPR83)
Cat.No IMG-5913A
Description G Protein-Coupled Receptor 83 (GPR83)
Format Purified, Peptide Affinity
Unit 0.1 mg
Price(USD) 278.00
MSDS
Catalog No
:
IMG-5913A
Contents
:
100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Isotype
:
Rabbit Ig
Clone
:
N/A
Purification
:
Antigen Affinity Chromatography
Species
:
Chimpanzee, Dog, Human, Monkey, Mouse, Rat
Predicted React
:
Cow, Chicken, Opossum
Host
:
Rabbit
Application
IHC (frozen): 2.5-5 ug/ml IHC (paraffin): 2.5-5 ug/ml Western blot analysis: 0.5-2 ug/ml Storage Store at 4°C, stable for 6 months. For long term storage, aliquot and store at -20°C. Recommended Positive Control : Brain
Background Principal Names: G-protein coupled receptor 83 (GPR83); GIR; GPR72; KIAA1540; HGNC:4534; Official Gene Symbol: GPR83 Gene ID: 10888 (human) Gene Map Locus: 11q21 (human)
GPR83, a 423 A.A protein, is an orphan member of GPCR protein family and is closely related to tachykinin and NPY receptors. It is a human homolog of mouse GIR protein and is exclusively expressed and selectively up-regulated in brain. It is a cell surface receptor protein consisting of a putative seven-transmembrane-domain. Reports suggest GPR83 might be involved in the regulation of immune tolerance mechanism by inducing peripheral generation of Foxp3+ Treg cells.
Antigen
A portion of amino acids 200-250 of human GPR83 was used as the immunogen.
Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, mouse, rat, chimpanzee, rhesus monkey and dog, 96% homologous in cow, 93% homologous in opossum and 80% homologous in chicken.
Western blot analysis of GPR83 in human brain lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse brain lysate and 4) rat brain lysate using IMG-5913A at 1 ug/ml.
Immunohistochemical analysis of frozen human brain (neurons & glia, A), frozen human tonsil tissue (lymphocytes, B), and formalin-fixed paraffin embedded human tonsil tissue (C) using IMG-5913A at 2.5 ug/ml.
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Reference 1. de Moerlooze, L. et al. Cytogenet Cell Genet. 90:146-150 (2000). 2. Hansen, W. et al. J. Immunol. 177:209-215 (2006).
Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
Related Products
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IMG-5913A [Peptide-affinity Purified Polyclonal Antibody to G Protein-Coupled Receptor 83 (GPR83) ]
