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Peptide-affinity Purified Polyclonal Antibody to FOXO1A |
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| Catalog No: |
IMG-5950A |
| Contents: |
100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic |
| Isotype: |
Rabbit Ig |
| Purification: |
Antigen-affinity chromatography |
| Species: |
Chimpanzee, Cow, Dog, Human, Mouse, New World monkey, Rat |
| Predicted React: |
Chicken, Opossum, Pufferfish |
| Host: |
Rabbit |
| Application: |
Western blot analysis: 0.05-0.50 ug/ml |
| Storage: |
Store at 4°C, stable for 6 months. For long-term storage, aliquot and store at -20°C |
Recommended
Positive Control: |
Human ovary |
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Background
FOXO1A is a 655 amino acid protein belonging to the forkhead family of transcription activators which is characterized by a distinct forkhead domain. The specific function of this protein has not yet been determined, however, it may play a role in myogenic growth and differentiation. It is also known to have a tumor suppressor function by inhibiting cell proliferation and survival. When fused to PAX3 it is known to cause alveolar rhabdomyosarcoma. |
Antigen
A portion of amino acids 250-300 of human FOXO1A protein was used as the immunogen. |
Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, mouse, monkey, chimpanzee, dog, rat and cow, 86% homologous in chicken, 91% homologous in puffer fish and 84% homologous in opossum. |
Genebank Info (Protein)
NP_002006 |
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Western blot analysis of FOXO1A in human ovary lysate in the 1) absence and 2) presence of immunizing peptide using IMG-5950A at 0.05 ug/ml. |
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Reference
1. Davis, RJ. et al. Proc. Nat. Acad. Sci. 94:8047-8051 (1997).
2. Huang, H. et al. Science. 314:294-297 (2006).
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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