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Datasheet
Polyclonal Antibody to microtubule-associated protein, RP/EB family, member 1 (MAPRE1) (Azide-free)
Cat.No IMG-6221E
Description MAPRE1
Format Azide-Free
Unit 0.1 mg
Price(USD) 257.00
MSDS
Catalog No
:
IMG-6221E
Contents
:
100 ug in 200 ul PBS. Filter sterilized. Sodium azide free.
Isotype
:
Rabbit IgG
Purification
:
Protein G chromatography
Species
:
Human
Predicted React
:
Mouse, Rat
Host
:
Rabbit
Application
Western blot analysis: 1:250-1:1000 Storage Aliquot and store at -20°C.
Background EB1 family proteins are evolutionarily conserved proteins that bind microtubule plus-ends and centrosomes and regulate the dynamics and organization of microtubules. The MAPRE genes encode the EB1 family proteins. The human MAPRE genes MAPRE1, MAPRE2, and MAPRE3 code for EB1, RP1, and EBF3 proteins, respectively. EB1 family members appear to be expressed ubiquitously. The EB1 (MAPRE1) gene, at 20q11.2, is fused to MLL in an adult patient with pro-B acute lymphoblastic leukemia. EB1 is a microtubule-associated protein that interacts with the colorectal adenomatous polyposis coli tumor-suppressor protein and plays important roles in regulating microtubule dynamics, cell polarity, and chromosome stability.
Antigen
A synthetic peptide corresponding to amino acids 228-242 (CQENEGENDPVLQRI) of human MAPRE1. Genbank accession no. NM_012325.
Western blot analysis of MAPRE1 in 1) transfected 293T cells and 2) untransfected 293T cells using IMG-6221A at 1:500.
Reference 1. Mimori-Kiyosue,Y., Shiina,N. and Tsukita,S. The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules. Curr. Biol. 10 (14), 865-868 (2000). 2. Tirnauer,J.S. and Bierer,B.E. EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability J. Cell Biol. 149 (4), 761-766 (2000). 3. Su LK, Qi Y. Characterization of human MAPRE genes and their proteins. Genomics. 71(2):142-149 (2001). 4. Fu JF, Hsu HC, Shih LY. MLL is fused to EB1 (MAPRE1), which encodes a microtubule-associated protein, in a patient with acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2005 Mar 4; [Epub ahead of print]
Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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