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Polyclonal Antibody to MERTK |
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| Catalog No: |
IMG-6302A |
| Contents: |
100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Isotype: |
Rabbit IgG |
| Purification: |
Protein A Chromatography |
| Species: |
Chimpanzee, Human, Mouse |
| Predicted React: |
Rhesus Monkey |
| Host: |
Rabbit |
| Application: |
Western blot analysis: 0.5-2.0 ug/ml |
| Storage: |
Store at 4°C, stable for 6 months. For long-term storage, aliquot and store at -20°C. |
Recommended
Positive Control: |
Spleen lysate |
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Background
MERTK is a novel transmembrane, receptor-like tyrosine kinase belonging to the MER/AXL/TYRO3 receptor kinase family with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and a tyrosine kinase domain. MERTK, a membrane protein, may have a functional role in filovirus infection, where it may act as a cell entry factor. MERTK is a GAS6 receptor, participating through binding to GAS6 in platelet function and platelet dependent thrombosis in vitro. Defects in MERTK have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). It is usually detected in normal peripheral blood monocytes, macrophages, bone marrow, and tissues of epithelial and reproductive origin. |
Antigen
A portion of amino acids 50-100 of human MERTK was used as the immunogen. |
Application Notes
The amino acid sequence used as immunogen is 100% homologous in human, chimpanzee, 77% homologous in rhesus monkey, and 55% homologous in mouse. |
Genebank Info (Protein)
NP_006334.2 |
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Western blot analysis of MERTK in human spleen lysate in the 1) absence 2) presence of immunizing peptide and 3) mouse spleen lysate using IMG-6302A at 2.0 ug/ml, 2.0 ug/ml and 0.5 ug/ml respectively. |
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Reference
1. Angelillo-Scherrer, A. et al. J. Clin. Invest. 115:237-246 (2005).
2. Ebermann, I. et al. Hum. Mutat. 28:571-577 (2007).
3. Thompson, DA. et al. Am. J. Hum. Genet. 70:224-229 (2002).
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Research purposes only.
Not for diagnostic or in vivo use. This product is guaranteed to perform as indicated on the datasheet for one year from the date of purchase.
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